前立腺における線維素溶解酵素に関する研究 第2編: 前立腺組織Actibatorについて

Abstract

1) Using Wistar-strain rats, the anterior lobe of the prostatic gland was extracted with normal saline and 2M KSCN and its fibrinolytic activity was determined with fibrin plate method. It was confirmed that its fibrinolytic activity is due to plasminogen activator and there was no action as plasmin. 2) Extirpation of various endocrine organes (pituitary gland, thyroid glands, thymus, adrenal glands and testicles) was performed followed by administration of testosterone propionate (TP) and estradiol benzoate (EB) in Wistar-strain rats. Changes of weight of prostatic gland and its tissue activator with KSCN extract were observed in each group. (a) Hypophysectomized group : A marked decrease in weight of the prostatic gland accompanied with decrease in tissue activator were demonstrated. (b) Thyroidectomized group : No significant cha n ge was seen in both of weight and tissue activator of the prostatic gland. (c) Thymectomized group : No significant change was seen in both of weight and tissue activator of the prostatic gland. (d) Adrenalectomized group : No change was seen in weight but slight decrease was found in tissue activator of the prostatic gland. (e) Castrated group : A marked decre a se in weight of the prostatic gland accompanied with a decrease in tissue activator were demonstrated in the prostatic gland. (f) With administration of TP, a marked increase in weight of t h e prostatic gland accompanied with an increase in tissue activator were recognized, while with administration of EB, reverse responses were demonstrated. 3) Tissue activator in histo l o gically proved squamous cell carcinoma of the prostatic gland, experimentally produced by injection of 20-methylcholanthrene, showed a slight increase above the control level.