尿路感染症とエンピナース

Abstract

Empynase is a proteolytic enzyme which has ability to diss o lve and clear the products of inflammatory lesion. It is reasonab l e , therefore, to use Empynase in combination with antibiotics for treatment of the infected lesion in order to make antibiotics easily spread into the lesion. In the present study Empynase was used for treatment of urinary tract in f e ctions. The results were satisfactory as follows : 1) Empynase was effective in five of eigh t patients with choromic prostatitis. 2) It was good for the patients with chronic pyelonephritis. 3) It was used in patients with traumatic pa r a plegics associated with urinary tract infections. The patients were divided at random into two groups in order to compare the effectiveness. Bacteriological cure was noted in only one of ten patients in the first group treated with a single administration of sensitive antibiotics, while it was achieved in five of eleven patients in the second group administered Empynase with sensitive antibiotics. Bacterial substitutions were encountered especially in the second group.