雄性副性器分泌液に関する研究 3:人精漿の臨床的研究 (殊に男性不妊症の蛋白,糖蛋白について)

Abstract

Protein and glucoprotein contents of the seminal plasm a in men were determined in the groups of normal controls and patients with sterility (oligospermia and azoospermia). Paper electrophoretic analysis was also performed on protein, glucoprotein and lipoprotein. The changes of these values following hormone treatment to the group of sterility were studied. 1) The protein contents of seminal plasma in the groups of normospermia(N), oligospermia( 0) and azoospermia(A) were 4.5-.-2.6 g m/dl, 4.8-1.5 gm/dl and 4.9-1.0 gm/d1 respectively, The glucoprotein contents in these subjects were 1, 791-597 mg/dl, 1, 492-328 mg/d1 and 1, 200-298 mg/dl respectively as galactose-mannose. 2) On electrophoresis, fine fracti o ns were separated for proteins which were called as I, II, III, IV, and 0 fraction from the anode to cathode. The III fraction in the N, 0 and A groups occupied 45.3, 42 5, and 41.0 % respectively, while the IV fraction in such groups showed 22.7, 24.7 and 27.8 % respectively, which indicated differences between the groups. The glucoprotein was demonstrated in the H, III and IV fractions. In the N, 0 and A groups, these glucoprotein showed 58.7, 55.6 and 50.3 % respectively in the III fraction and 30.2, 35.5 and 39.8 % respectively in the IV fraction as percent distributions. No lipoprotein was found in every fraction. 3) Administration of TH an d PMS to the patients with sterility resulted no noticeable change in protein content but distinct increase in glucoprotein content in many cases. On the electrophoretic pattern, slight increases of the III fraction and decreases of the IV fraction were demonstrated on both protein and glucoprotein distributions.