胸管ドレナージ法の同種腎移植への応用

Abstract

Prolonged thoracic duct lymph drainage was performed in a total of 7 patients with far advanced chronic renal insufficiency. In one case the drainage was done immediately after renal homotransplantation and one other patient was cannulated 12 days prior to renal homotransplantation. The daily average lymph flow ranged from 765 ml to 1, 517 ml with a mean volume of 1, 200 ml during a period varying from 10 to 43 days. The average daily depletion of lymphocyte was 3.3x109. The to t a l lymphocyte count in circulating peripheral blood significantly decreased within 10 days following lymph drainage and the lymphopenia continued until death of patients. Prolonged thoracic duct lymph drainage appears to be useful in patients requirin g kidney homotransplantation for chronic renal insufficiency, since this technique can reduce edema, inhibit BUN elevation and induce lymphocyte depletion. It may be possible that the dosage of immuno s uppressive drug is reduced by application of the duct drainage and the death due to drug toxicity is avoided.