フラダンチン50mg錠の使用経験

Abstract

Nitrofurantoin, composed by Dodd and Stillman in 1944 is most widely used for various urological infections. However, side effects of this drug, especially nausea, vomiting and other gastrointestinal disturbances can not be overlooked when given in large dose. Occurrence of these untoward effects in remarkable percentage of patients was reported by Mintzer, Hasen and Carroll. In this paper, th e effectiveness and the side effects were examined by giving 50 mg enterocoated tablets of Furadantin. Fifty two cases of urinary tract infections were treated with oral administration of 200 mg per day for adult. Of 52 cases, 73.1 % was well controlled and clinica l ly cured, while the side effects were observed in only 12.3 % (nausea 6, vomiting 1 and fever 1 : 8 cases). These results indicate that this method of administration reduce d the side effects by using 100 mg enterocoated tablets in a daily dose of 400 mg. To confirm the effectiveness, the average urinary c oncentration of Furadantin after oral administration of 50 mg tablet was measured on three normal adults. It was found that the urine level has kept above 60 mcg/ml for 6 hours. This level appeared to suppress most agents in u rine of the urinary tract infection, because it was demonstrated that the minimal inhibitory ccncentration of this drug was less than 50 mcg/ml on 181 strains cultured from various urological infections in our division. Moreover this concentration effected in similar manner to almost all of 22 multiresistant gram-negative strains which had been cultured from patients.