泌尿器科領域におけるDR-108の使用経験

Abstract

A new contrast medium for the urinary tracts and b l o od vessels, DR'-108, was used in 50 cases for intravenous pyelography and 24 cases for renal arteriography. For the same subjects, 76 % Diatrizoate was used to compare the contrasting effect, speed of administration and side effect of DR-108. The results obtained are summarized as follows. 1) The contrasting effect of DR-108 was almost identical or better in some cases than Diatrizoate to obtain clear pyelogram or renoarteriogram. 2) For both of intravenous pyelography a n d renal arteriography DR-108 was able to give rapidly. The intravenous administration was easily completed within 39 second as the average for IVP and at the speed rate of 10 ml per second for renoarteriography, in which this rate is requested to obtain clear contrast. 3) As the side effect, no noticeable evide n ce was observed in both of IVP and renal arteriography. Effect of DR-108, of which massive dose was given into abdominal aorta of adult dog, on the kidney was studied by renal biopsy and determination of blood NPN and the results showed no remarkable change following administration. The above results suggest that DR-108 is an excellent contrast medium for the urinary tract and blood vessels.