Dithizoneの前立腺に対する影響 第3編: 犬前立腺に対するDithizone局所注入の影響について

Abstract

In the preceding experiments, it was found that, in rats, administration of Dithizone produces marked damage in the prostatic epithelial cells along with fairly severe generalized side effects. Therefore, use of Dithizone for treatment of cancer of the prostatic gland has to be considered hesitatingly due to its side effects. This report deals with the results of local injection of Dithizone into the prostatic gland of male adult dog to observe histological changes as well as generalized influences. 1) Dithizone was solved in propylene glycol a nd injected into the prostatic tissue under laparotomy. 2) As macroscopic change after Dithizone injection, atrophy was observed in the injected side compare to the control side. 3) As histological change after D i t hizone injection, necrosis, bleeding and disappearance of glandular structure were demonstrated by 20 days after injection. Subsequently, however, gradual regenerative process took place until recovery of normal prostatic structure was exibited. 4 ) Results of examinations of serum total protein, A-G ratio, urea N, creatinine, GOT, GPT, total cholesterol, cholesterol ester, serum Na, K, Cl, P, HCO3 and blood sugar indicated that local administration of Dithizone supposed to give almost no response on generalized condition. Based on the above results, it might be expected that Dithizone treatment can be applicable for human prostatic cancer clinically.