抗生物質療法と蛋白分解酵素 尿路感染症におけるVaridase Oral併用の臨床的検討

Abstract

A proteolytic enzyme "Varidase Oral" was administer e d accompanied with antibiotics to patients with various urinary tract infections. The results obtained are summarized as follows. 1. In the cases of non-gonococcal urethritis, the combination of "Varidase Oral" made the course required disapperance of morning discharge shortened along with marked improvement of microscopic findings. 2. In the cases of simp l e inflammations such as acute cystitis, the combination therapy was not always necessary. Single therapy with antibiotics was sufficiently effective to cure the diseases within a short term. 3. For chronic pyelonephritis, "Varidase Oral" administration was effective to obtain early and marked improvements of urinary findings as well as pyelographic figures. It was though that the drug is better to be given along with antibiotics actively from the early course of treatment. 4. In cases o f postoperative fistel formation, the combination therapy made the course to close the fistel shortened, although the duration required to eliminate secration was not altered. In cases of postoperative cystitis and postoperative refractory infections with complications, the therapeutic course was expected to be shortened by the combined administration. 5. Studies performed before and after the therapy given more than 4 weeks disclosed no noticeable side effects on blood pictures, liver functions and serum protein findings.