副性器分泌液の糖蛋白に関する研究 第3編: 人精漿,殊に男性不妊症の場合について

Abstract

Biochemical determinations of mucoprotein (MP) and muc o polysaccharide (MPS) were made on human seminal plasma obtained from normospermic, oligospermic and azoospermic groups. For the sterility group, change of MP and MPS in seminal plasma was observed before and following hormone therapy. The results are summarized as follows. 1) The average values of MP and MPS in seminal plasm a were 10.8 mg/dl and 874 r /m1 respectively in the normospermic group, were 9.8 mg/dl and 815 r/ml respectively in the oligospermic group and were 9.1 mg/dl and 790 γ/m1 respectively in the azoospermic group. For both of MP and MPS, the average values were higher in the normospermic group and lower in the sterility groups. 2) Altho u gh there was no significant correlation between amount of seminal fluid and values of MP and MPS, higher values were seen in 2 to 4 ml groups. 3) Patients with male sterility were treated with te s t osterone heptanoate 100 mg every 20 days and PMS 1, 000 i. u. twice a week for 60 days. Among 6 patients with oligospermia, increases in number of spermatozoa and in contents of MP and MPS in seminal plasma were demonstrated in 3 for MP and in 4 for MPS following the treatment. Among 3 patients who showed increase in amount of seminal fluid, contents of MP and MPS also showed increases in 3 and 2 patient respectively. In the group of azoospermia, all of 4 patients who showed increase in amount of seminal fluid also demonstrated increases in MP and MPS contents in the seminal plasma. On th e basis of these results, it was suggested that there exists a relationship between MP and MPS contents in seminal plasma and secreting function of the male accessory sexual organs or conceptivity.