乳糜尿に対するα-Chymotrypsin(キモプシン)の臨床効果について

Abstract

A ferment drug, a-chymotrypsin, was given to 4 patient s with chyluria followed by disapperance of chyuria clinically. The usage of the drug was designed as the following manner. 1) Bladder irrigation with 500 cc of isotonic saline containing 25 units of chymo t rypsin was tried several times a day which resulted in decrease of fibrin clot and improvement of dysuria. 2) About 20 ml of solution containing 25 units of chymotrypsin was poured into the bladder through a urethral catheter and left it for about 2 hours until the bladder was filled with urine. 3) Chymotrypsin was given orally at the dosage of 100 units per day. 4) Chymotrypsin was given intramuscularlly at the dosage of 2 5 units once or twice a week. A combination therapy of the above mentioned oral, intramuscular and either one of intravesical administrations of chymotrypsin was done for 2 weeks to 1 month which resulted in disapperance of chyluria. No noticeable side effect was encountered with the exception of one case who died of cancer of the lung. No relapse has been noted during the follow-up observation for over 8 months. It is concluded that the drug is effective clinically for chyluria.