前立腺肥大症患者における夜間頻尿の原因と夜間頻尿に対するナフトピジルの有用性について - Frequency volume chartsを用いた検討 -

Abstract

Frequency Volume Charts(FVG)を用いて, 前立腺肥大症患者における夜間頻尿の原因について検討を行った.更に, FVGが得られた症例のうち治療を要すると判断された前立腺肥大症の患者70例を対象として, FVGの観点から夜間頻尿に対するナフトピジルの作用機序について検討を行った.その結果, 半数近い患者が夜間多尿による夜間頻尿であることが明らかとなり, 合併群を含めると7割弱の患者に夜間多尿が関係しているという結果が得られた.FVGの結果から, ナフトピジルは1回排尿量を増加させることにより夜間頻尿を改善させることが明らかとなった

The etiology of nocturia in 70 patients with benign prostatic hyperplasia (BPH) who had nocturia of two or more times were examined based on frequency volume charts (FVC). Nocturia was classified into four groups: nocturnal polyuria, low capacity, combined nocturia, and no evidence of abnormality. Nearly half of the cases had nocturnal polyuria only. A little under 70% of patients had associated nocturnal polyuria (nocturnal polyuria+combined nocturia). Naftopidil was administered for three months to the patients with BPH who had nocturia with a urinary frequency of two or more times. Clinical efficacy was evaluated in 32 patients based on FVC and naftopidil was shown to improve nocturia. The improvement in nocturia was determined by the increment in voided volume.