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Title: 膀胱上皮内癌に対するBCG40mg6回膀胱腔内注入療法の検討
Other Titles: Intravesical Bacillus Calmette-Guerin (BCG : Tokyo 172 strain) instillation for carcinoma in situ of the bladder : results with 6 successive instillations of 40 mg BCG
Authors: 麦谷, 荘一  KAKEN_name
永田, 仁夫  KAKEN_name
高山, 達也  KAKEN_name
大園, 誠一郎  KAKEN_name
伊藤, 寿樹  KAKEN_name
丸山, 哲史  KAKEN_name
波多野, 伸輔  KAKEN_name
永江, 浩史  KAKEN_name
Author's alias: Mugiya, Soichi
Nagata, Masao
Takayama, Tatsuya
Ozono, Seiichiro
Ito, Toshiki
Maruyama, Satoshi
Hadano, Shinsuke
Nagae, Hiroshi
Keywords: Bcg
Carcinoma in situ
Bladder cancer
Tokyo 172 strain
Low dose
Issue Date: Jul-2004
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 50
Issue: 7
Start page: 469
End page: 473
Abstract: 膀胱上皮内癌(CIS)に対するBCG 40mg・6回膀胱内注入療法を検討した.対象は,膀胱CISと診断された43例(男性35例,女性8例・平均67.5歳)で,Primary CIS(13例)とSecondary CIS(30例)に分けて評価し,BCGは40mgを週1回,計6回連続膀胱内注入とした.その結果,1)成績はPrimary CISでCR 11例(84.6%),NC 2例,Secondary CISで各々25例(83.3%),5例であった.2)CR持続期間中央値はPrimary CIS 29ヵ月,Secondary CIS 36ヵ月,非再発率は12ヵ月で97.2%,36ヵ月で70.7%であった.3)CR例で膀胱内再発11例,尿管癌1例を認め,BCG再投与(5例),TUR-Bt(6例),腎尿管全摘術(1例)施行で現在も再発・転移を認めていない.4)NC7例中5例は再度BCG6回投与でCRとなり,他の1例は膀胱全摘術施行,1例は陰性化せず来院しなくなった.5)副作用は膀胱刺激症状21例(48.8%),膿尿20例(46.5%),肉眼的血尿8例(18.6%),発熱4例(9.3%)を認めた
We performed a study to evaluate the usefulness of intravesical Bacillus Calmette-Guerin (BCG: Tokyo 172 strain) instillation on carcinoma in situ (CIS) of the bladder. Between 1998 and 2003, 43 patients were treated for CIS of the bladder with a median follow-up period of 45 months (range: 12 to 69 months). The patients (35 males and 8 females) ranged in age from 45 to 89 years (average: 67.5 years). They underwent intravesical instillation of 40 mg of BCG once a week for 6 weeks. A complete response (CR) was achieved in 83.7% of the patients. Among these patients, 97.2% and 70.7% remained recurrence-free during follow up for one year and three years, respectively. The median duration of CR was 31.5 months. Although total cystectomy was performed on 1 patient, none of the patients died of bladder cancer. Adverse effects included bladder irritability in 48.8%, pyuria in 46.5%, gross hematuria in 18.6%, and fever (temperature over 37.5 degrees C) in 9.3%. No clinically significant side effects were observed. These results indicate that intravesical instillation of BCG at a dose of 40 mg given 6 times was as effective as the routine dose of 80 mg, and could decrease systemic adverse effects such as high fever.
PubMed ID: 15334890
Appears in Collections:Vol.50 No.7

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