ダウンロード数: 691
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
50_469.pdf | 237.73 kB | Adobe PDF | 見る/開く |
タイトル: | 膀胱上皮内癌に対するBCG40mg6回膀胱腔内注入療法の検討 |
その他のタイトル: | Intravesical Bacillus Calmette-Guerin (BCG : Tokyo 172 strain) instillation for carcinoma in situ of the bladder : results with 6 successive instillations of 40 mg BCG |
著者: | 麦谷, 荘一 永田, 仁夫 高山, 達也 大園, 誠一郎 伊藤, 寿樹 丸山, 哲史 波多野, 伸輔 永江, 浩史 |
著者名の別形: | Mugiya, Soichi Nagata, Masao Takayama, Tatsuya Ozono, Seiichiro Ito, Toshiki Maruyama, Satoshi Hadano, Shinsuke Nagae, Hiroshi |
キーワード: | Bcg Carcinoma in situ Bladder cancer Tokyo 172 strain Low dose |
発行日: | Jul-2004 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 50 |
号: | 7 |
開始ページ: | 469 |
終了ページ: | 473 |
抄録: | 膀胱上皮内癌(CIS)に対するBCG 40mg・6回膀胱内注入療法を検討した.対象は, 膀胱CISと診断された43例(男性35例, 女性8例・平均67.5歳)で, Primary CIS(13例)とSecondary CIS(30例)に分けて評価し, BCGは40mgを週1回, 計6回連続膀胱内注入とした.その結果, 1)成績はPrimary CISでCR 11例(84.6%), NC 2例, Secondary CISで各々25例(83.3%), 5例であった.2)CR持続期間中央値はPrimary CIS 29ヵ月, Secondary CIS 36ヵ月, 非再発率は12ヵ月で97.2%, 36ヵ月で70.7%であった.3)CR例で膀胱内再発11例, 尿管癌1例を認め, BCG再投与(5例), TUR-Bt(6例), 腎尿管全摘術(1例)施行で現在も再発・転移を認めていない.4)NC7例中5例は再度BCG6回投与でCRとなり, 他の1例は膀胱全摘術施行, 1例は陰性化せず来院しなくなった.5)副作用は膀胱刺激症状21例(48.8%), 膿尿20例(46.5%), 肉眼的血尿8例(18.6%), 発熱4例(9.3%)を認めた We performed a study to evaluate the usefulness of intravesical Bacillus Calmette-Guerin (BCG: Tokyo 172 strain) instillation on carcinoma in situ (CIS) of the bladder. Between 1998 and 2003, 43 patients were treated for CIS of the bladder with a median follow-up period of 45 months (range: 12 to 69 months). The patients (35 males and 8 females) ranged in age from 45 to 89 years (average: 67.5 years). They underwent intravesical instillation of 40 mg of BCG once a week for 6 weeks. A complete response (CR) was achieved in 83.7% of the patients. Among these patients, 97.2% and 70.7% remained recurrence-free during follow up for one year and three years, respectively. The median duration of CR was 31.5 months. Although total cystectomy was performed on 1 patient, none of the patients died of bladder cancer. Adverse effects included bladder irritability in 48.8%, pyuria in 46.5%, gross hematuria in 18.6%, and fever (temperature over 37.5 degrees C) in 9.3%. No clinically significant side effects were observed. These results indicate that intravesical instillation of BCG at a dose of 40 mg given 6 times was as effective as the routine dose of 80 mg, and could decrease systemic adverse effects such as high fever. |
URI: | http://hdl.handle.net/2433/113411 |
PubMed ID: | 15334890 |
出現コレクション: | Vol.50 No.7 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。