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タイトル: | ホルモン不応性前立腺癌に対するタキサン系薬剤の有効性 |
その他のタイトル: | Effectiveness of taxanes-based chemotherapy against hormone-refractory prostate carcinoma |
著者: | 白木, 良一 桑原, 勝孝 櫻井, 孝彦 丸山, 高広 星長, 清隆 |
著者名の別形: | Shiroki, Ryoichi Kuwahara, Yoshitaka Sakurai, Takahiko Maruyama, Takahiro Hoshinaga, Kiyotaka |
キーワード: | Hormone-refractory prostate carcinoma Chemotherapy Taxanes |
発行日: | Jun-2006 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 52 |
号: | 6 |
開始ページ: | 481 |
終了ページ: | 485 |
抄録: | We performed an investigative and clinical study of docetaxel, and evaluated its efficacy against hormone-refractory prostate carcinoma (HRPC). In an in vitro experiment, docetaxel suppressed the human prostate cell line proliferation not only in an androgen-dependent cell line, LNCaP, but also in androgen-independent cell line, PC-3, in a dose-dependent manner. In an in vivo experiment applying an SCID mouse xenograft model with PC-3, docetaxel administration suppressed the tumor growth more than 95%. In a clinical study, eight cases were enrolled to low-dose (20 mg/m2/wk) weekly regimen and an other eight to high-dose (60 mg/m2/wk) administration of docetaxel every three weeks. A prostate specific antigen (PSA) decline of more than 50% were observed in 4 (50%) in the low-dose group and 5 (63%) in the high-dose group. The median time to progression and overall survival were 8.5 and 13.2 months in the low-dose group and more than 5.5 and 8.5 months in the high-dose one, respectively. This regimen was well tolerated, and the incidence of adverse effect was relatively low and light. Grade 3 neutropenia or leukocytopenia without fever was seen in three patients (18.8%). Only one patient required administration of granulocyte-colony stimulating factor because of neutropenia. No other grade 3 or 4 toxicity was observed. In conclusion, docetaxel-based chemotherapy was well tolerated and an active treatment for HRPC cases. |
URI: | http://hdl.handle.net/2433/113868 |
PubMed ID: | 16848362 |
出現コレクション: | Vol.52 No.6 |
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