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タイトル: Significance of portal venous VEGF during liver regeneration after hepatectomy.
著者: Yamamoto, Chiduru
Yagi, Shintaro  KAKEN_id  orcid https://orcid.org/0000-0001-7465-5761 (unconfirmed)
Hori, Tomohide
Iida, Taku
Taniguchi, Kentaro
Isaji, Shuji
Uemoto, Shinji  KAKEN_id
著者名の別形: 八木, 真太郎
キーワード: liver regeneration
portal vein
VEGF
HIF-1α
HGF
HGFA
spleen
intestine
partial hepatectomy
発行日: Apr-2010
出版者: Elsevier
誌名: The Journal of surgical research
巻: 159
号: 2
開始ページ: e37
終了ページ: e43
抄録: BACKGROUND: Although some studies have hypothesized portal venous blood is important for liver regeneration, no studies have established organs whose venous effluent flow into the portal vein secrete liver regenerating factors into the portal vein during liver regeneration. The aim of this study was to elucidate up-regulation of vascular endothelial growth factor (VEGF) in the portal vein, and expressions of hepatic regenerating factors in organs whose venous effluent flows into the portal vein during liver regeneration. MATERIALS AND METHODS: VEGF protein in systemic and portal venous blood, as well as expression of VEGF, hypoxia-inducible factor-1alfa (HIF-1alpha), hepatocyte growth factor (HGF), and HGF activator (HGFA) mRNA were evaluated in the regenerating liver, spleen, and intestine following 70% partial hepatectomy (PHx) in rats. RESULTS: The portal VEGF protein level was significantly higher than the systemic level post-PHx (portal/systemic at 72, 120, and 168 h post-PHx: 17.2/13.0, 20.2/12.8, and 24.0/14.7 pg/mL; P = 0.003, P = 0.022 and P = 0.032, respectively). VEGF mRNA expressions were significantly higher in the liver (P = 0.000027: 168 h), spleen (P = 0.000059: 72 h) and intestine (P = 0.01: 24-72 h) post-PHx compared with pre-PHx. HIF-1alpha, HGF, and HGFA mRNA expressions in the liver, intestine, and spleen were also significantly higher post-PHx compared to pre-PHx. CONCLUSIONS: Portal VEGF was significantly higher than systemic VEGF, and expressions of VEGF, HIF-1alpha, HGF, and HGFA mRNA in the liver, spleen and intestine were also up-regulated during liver regeneration. These results suggest that hepatic regenerating factors derived from the spleen or intestine may contribute liver regeneration.
著作権等: © 2010 Elsevier B.V.
This is not the published version. Please cite only the published version.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/113888
DOI(出版社版): 10.1016/j.jss.2008.11.007
PubMed ID: 19394640
出現コレクション:学術雑誌掲載論文等

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