膀胱癌M-VAC動注併用化学療法における局所静脈内薬剤濃度の検討

Abstract

膀胱癌8例に動注併用M-VAC化学療法を施行し, CDDP動注時に内腸骨静脈内及び末梢静脈内Pt濃度を測定した. 1)内腸骨静脈内総Pt濃度は, 15.13±10.13(μg/ml), Free Pt濃度は, 8.08±7.98(μg/ml).この時末梢静脈Pt濃度は総4.11±1.72, Free Pt2.00±1.59(μg/ml). 2)動注時の局所静脈内薬剤濃度は, 末梢静脈薬剤濃度の約4倍. 3)動注時も末梢血薬剤濃度は静脈投与時と同等に認められ, このため, 動注併用M-VAC化学療法時も副作用は静脈投与時と同等に発現する

We evaluated the usefulness of internal iliac artery infusion of cisplatin (CDDP) in the M-VAC therapy for bladder cancer. CDDP (average 72 mg) was administered into the internal iliac artery with an infusion time of 15 minutes in 8 cases of bladder cancers. After the end of CDDP intra-arterial injection, we measured the total and free platinum (Pt) levels in the internal iliac venous blood and systemic venous blood. Both total and free platinum levels in the internal iliac venous blood were about 4 times higher than those in the systemic vein. No significant difference was found in total or free platinum level in the systemic blood between the intra-arterial and intra-venous infusion methods. Intra-arterial CDDP therapy is effective in the treatment of the local tumor and systemic micrometastasis.