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Title: 難治性精巣腫瘍に対するPBSCT併用超大量化学療法 - PBSCT研究会・精巣腫瘍分科会による多施設共同臨床試験 -
Other Titles: High-dose chemotherapy with peripheral blood stem cell autotransplantation for patients with poor-risk testicular germ cell tumors--pilot study of the Japan Blood Cell Transplantation Study Group
Authors: 中川, 修一  KAKEN_name
三木, 恒治  KAKEN_name
赤座, 英之  KAKEN_name
大園, 誠一郎  KAKEN_name
岡野, 達弥  KAKEN_name
薗田, 精昭  KAKEN_name
塚本, 泰司  KAKEN_name
寺地, 敏郎  KAKEN_name
内藤, 克輔  KAKEN_name
内藤, 誠二  KAKEN_name
西山, 勉  KAKEN_name
野々村, 祝夫  KAKEN_name
原, 勲  KAKEN_name
星, 宣次  KAKEN_name
吉田, 修  KAKEN_name
Author's alias: NAKAGAWA, Shuichi
MIKI, Tsuneharu
AKAZA, Hideyuki
OZONO, Seiichiro
OKANO, Tatsuya
SONODA, Yoshiaki
TSUKAMOTO, Taiji
TERACHI, Tosiro
NAITO, Katsusuke
NAITO, Seiji
NISHIYAMA, Tsutomu
NONOMURA, Norio
HARA, Isao
HOSHI, Senji
YOSHIDA, Osamu
Keywords: Testicular tumor
PBSCT
High-dose chemotherapy
Japan Blood Cell Transplantation Study Group
Pilot study
Issue Date: Nov-1999
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 45
Issue: 11
Start page: 805
End page: 809
Abstract: Indiana分類advanced disease 42例のうちBEP療法3コース終了後に,腫瘍マーカーが正常化しなかった16例に対してPBSCT併用超大量化学療法を1コース行い検討した.超大量化学療法1コースでは十分な効果があるとはいえなかった.とくにhCG-βが高値の症例に対しては効果が不十分であった.BEP療法によるPBSCの採取効率は良好で,移植後の造血機能回復も速やかであった
The efficacy and toxicity of a single cycle of high-dose chemotherapy with peripheral blood stem cell autotransplantation (PBSCT) in patients with poor-risk testicular germ cell tumors (GCT) enrolled in the Japan Blood Cell Transplantation Study Group was investigated. Previously untreated poor-risk testicular GCT patients were treated with BEP therapy (cisplatin, etoposide and bleomycin) with or without high-dose chemotherapy (carboplatin, etoposide and ifosphamide) followed by PBSCT. Patients were qualified for a change to high-dose chemotherapy if elevated serum tumor markers (human chorionic gonadotropin-beta, alpha-fetoprotein and lactate dehydrogenase) was observed after 3 cycles of BEP therapy. Eighteen patients were treated with BEP therapy alone and 16 with BEP and high-dose chemotherapy. At the completion of high-dose chemotherapy, all tumor markers had returned to normal in 6 patients. Among them, 1 had only teratoma found at resection and 5 had carcinoma resected. Nine patients who had persistent elevation of any tumor marker were treated with high-dose chemotherapy or another anticancer drug. Thirteen are alive (81%) and 9 (56%) are continuously disease-free at a median follow up of 11 months. The median time from PBSCT to a granulocyte count > 500/microL was 9.5 days and to a platelet count > 50,000/microL was 13 days.
URI: http://hdl.handle.net/2433/114151
PubMed ID: 10637748
Appears in Collections:Vol.45 No.11

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