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Title: 浸潤性膀胱癌に対する白金製剤を用いた化学放射線併用療法
Other Titles: Concurrent platinum-based chemotherapy and radiotherapy for locally advanced bladder cancer
Authors: 中逵, 弘能  KAKEN_name
山下, 与企彦  KAKEN_name
橋根, 勝義  KAKEN_name
住吉, 義光  KAKEN_name
Author's alias: NAKATSUJI, Hiroyoshi
HASHINE, Katsuyoshi
SUMIYOSHI, Yoshiteru
Keywords: Bladder cancer
Issue Date: Nov-1999
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 45
Issue: 11
Start page: 745
End page: 748
Abstract: 根治的膀胱全摘除術や動注化学放射線療法が施行できない浸潤性膀胱癌に対して,白金製剤を用いた全身化学放射線併用療法を行い,8例中6例のCRが得られ,有害事象に関しても寛容であった
Eight patients with locally advanced bladder cancer who were not candidates for radical cystectomy or concurrent intra-arterial chemotherapy and radiotherapy were treated with combined platinum-based chemotherapy and radiation therapy. Six of the eight patients (75%) achieved a clinical complete response (CR). The effect of therapy in four patients whose histopathological responses were evaluated was effect grade 3. One of the eight patients died of treatment-related myelosuppression. The other two patients died of intercurrent disease, while the remaining five patients are alive with preservation of a functional bladder. The 2-year overall survival rate was 87.5%. Adverse events due to chemotherapy were mainly bone marrow suppression. Those caused by radiation therapy were rectal irritability. We considered concurrent platinum-based chemotherapy and radiotherapy useful for the treatment of locally advanced bladder cancer.
PubMed ID: 10637735
Appears in Collections:Vol.45 No.11

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