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タイトル: 膀胱癌における尿中NMP22(Nuclear matrix protein 22)の有用性の検討
その他のタイトル: Clinical evaluation of urinary nuclear matrix protein 22 as a marker for bladder cancer
著者: 黒川, 真輔  KAKEN_name
森田, 辰男  KAKEN_name
村石, 修  KAKEN_name
徳江, 章彦  KAKEN_name
著者名の別形: KUROKAWA, Shinsuke
MORITA, Tatsuo
MURAISHI, Osamu
TOKUE, Akihiko
キーワード: Bladder cancer
Nuclear matrix protein 22
Bladder tumor antigen test
Urinary cytology
Tumor marker
発行日: Apr-2001
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要
巻: 47
号: 4
開始ページ: 247
終了ページ: 250
抄録: 尿路感染症を合併していない膀胱癌患者において, 尿中NMP22はBTAテストより感受性の高い検査法であるが, 尿細胞診と比較すると陽性率は同等であった.しかし, 尿中NMP22と尿細胞診とを併用すれば, 単独よりも膀胱癌のモニタリングに有用と思われた
The purpose of this study is to evaluate the clinical usefulness of urinary nuclear matrix protein 22 (NMP22) as a marker for bladder cancer. We examined the positive rates of NMP22 test, urinary cytology and bladder tumor antigen (BTA) test, and compared the positive rate of NMP22 test with that in urinary cytology and BTA test. Urine samples were obtained from 50 patients with histologically confirmed bladder cancer before the treatment. The samples were examined by NMP22 test, urinary cytology and BTA test. In 50 patients with bladder cancer, the overall positive rate was 40% for NMP22 test, 40% for urinary cytology, and 16% for BTA test. A combination of NMP22 test and urinary cytology showed a significantly higher positive rate (54%) as compared to NMP22 test or urinary cytology alone. When NMP22 test and urinary cytology were compared for tumor size, number, shape, stage and grade, NMP22 test showed a significant higher positive rate than urinary cytology in grade 1 bladder cancer. In conclusion, although NMP22 test and urinary cytology gave a similar positive rate, a combination of NMP22 test and urinary cytology is more useful than the NMP22 test or urinary cytology alone for monitoring of bladder cancer.
URI: http://hdl.handle.net/2433/114506
PubMed ID: 11411098
出現コレクション:Vol.47 No.4

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