泌尿器科領域内での重複癌についての検討

Abstract

1980～1999年に泌尿器科領域内で治療した腎細胞癌300例, 尿路上皮癌661例, 前立腺癌381例を対象に検討し, 以下の結果を得た.1)計20例の重複癌症例を含め, 全て二重癌であった.腎細胞癌を含むもの7例, 移行上皮癌を含むもの14例, 前立腺癌を含むもの19例であった.2)重複癌の組合せは, 腎細胞癌と移行上皮癌1例, 腎細胞癌と前立腺癌6例, 移行上皮癌と前立腺癌13例であった.3)前立腺癌の増加に伴って, 近年急速に増加傾向にある.4)喫煙歴のあるもの11例, ないもの7例, 不明2例であった.家族歴では二親等以内の血縁者に悪性腫瘍の発生を認めるのは20例中5例であった.5)経過観察期間は38ヵ月で, 癌なし生存6例, 癌有り生存6例, 癌死6例(前立腺癌4例, 腎細胞癌2例), 他因死2例であった

We analyzed the clinical features of multiple primary cancers arising from the urogenital organs. Between January 1980 and December 1999, 300 patients with renal cell carcinoma (RCC), 661 patients with urothelial carcinoma (bladder cancer and renal pelvic-ureteral cancer) (TCC) and 391 patients with prostate cancer (PC) were treated at our hospital. Of these patients, 20 patients had double genitourinary cancers. The double cancers consisted of RCC and TCC in 1 case, RCC and PC in 6 cases, and TCC and PC in 13 cases. Seven cases had synchronous tumors. The average interval in the metachronous cases was 68 (range: 12-209) months. The age at diagnosis of the second cancer was 68-94 (mean: 77.6) years old. The follow-up period ranged from 4-168 (mean: 38) months; Six patients are alive with no evidence of disease and 6 patients died of cancer. Even when limited to the urological section, the frequency of multiple primary cancers is increasing.