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タイトル: | 泌尿器科腫瘍学における分子研究の展望 : 腎細胞癌の発癌・転移とMN/CA9 |
その他のタイトル: | The role of MN/CA IX antigen in carcinogenesis and metastasis of renal cell carcinoma |
著者: | 仲川, 嘉紀 植村, 天受 清水, 一宏 趙, 順規 吉川, 元祥 平尾, 佳彦 吉川, 和宏 |
著者名の別形: | NAKAGAWA, Yoshinori UEMURA, Hirotsugu SHIMIZU, Kazuhiro CHO, Masaki YOSHIKAWA, Motoyoshi HIRAO, Yoshihiko YOSHIKAWA, Kazuhiro |
キーワード: | Renal cell carcinoma MN/CA9 Carcinogenesis Metastasis |
発行日: | Nov-2001 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 47 |
号: | 11 |
開始ページ: | 809 |
終了ページ: | 814 |
抄録: | MN/CA IX is a carbonic anhydrase (CA) isoenzyme expressed in normal alimentary tract in a tissue-specific manner. This antigen is activated in the majority of renal cell carcinomas (RCC) but not in normal kidney tissues. Although the exact role of CA activity in carcinogenesis and metastasis has not been established, MN/CA9 has been suggested to be implicated in acidification of extracellular milieu surrounding the cancer cells and thus create a microenvironment conductive to tumor growth and spread. Mutations in the von Hippel-Lindau (VHL) gene cause the familial syndrome and are also found in the majority of sporadic RCC. Wild-type VHL was recently described to down-regulate MN/CA9 in RCC cell lines, and the molecular mechanism of MN/CA9 and VHL in renal carcinogenesis is of interest. To investigate the mechanism of MN/CA9 activation in RCC, we examined the methylation status of this gene in RCC cell lines and human tissue samples and found that hypomethylation in the promoter region may play an important role in the expression of MN/CA9. RT-PCR analysis of blood samples from RCC patients revealed the presence of circulating MN-positive cells in the blood. This antigen may be a potential therapeutic target as well as diagnostic marker for RCC. Therefore, we are currently investigating whether or not MN/CA IX peptide could be an appropriate molecule for use antigen specific immunotherapy on RCC patients. |
URI: | http://hdl.handle.net/2433/114641 |
PubMed ID: | 11771176 |
出現コレクション: | Vol.47 No.11 |
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