前立腺肥大症に対する漢方製剤:柴苓湯の有用性の検討 ―夜間頻尿症状の改善効果についての検討―

Abstract

一晩に3回以上の排尿がある夜間頻尿症状を有する前立腺肥大症患者12名を対象に, カネボウ柴苓湯エキス細粒の有用性について検討した.柴苓湯は1日2回の投与で改善以上12%, やや改善以上66.7%の結果が得られた.症状ごとの検討では, 日中尿量を有意に増加させ, 夜間尿量, 排尿回数ともに有意に減少させた.投与前後を比較して, 自覚症状が有意に改善し, 高齢者の夜間頻尿がもたらす一番の問題点といえるQOLの低下に有意な改善効果が確認された.本剤投与によると思われる副作用は認められなかった.以上の結果から, 前立腺肥大症患者の夜間頻尿症状に対する本剤の効果は, 比較的軽症例に高く, 有効な薬剤であることが示唆された

Prostatic hyperplasia is characterized by major voiding symptoms, and treatment aims principally at improving the quality of life. Nocturnal frequency is a primary symptom that markedly impairs the quality of life. In addition to alpha 1-receptor blockers and antiandrogen agents, herbal medicines and kampo preparations have also been used, but they have not always proved satisfactory. In this study, we investigated the effect of a diuretic kampo preparation (Kanebo Saireito Extract Fine Granules) on urine output, and evaluated the efficacy of Saireito (5.4 g/day, bid) in 12 patients (mean age, about 68) with prostatic hyperplasia who had completed basic therapy but still complained of nocturnal frequency. The following results were obtained. 1) Saireito caused a significant increase of daytime urine output and significantly reduced nocturnal output. 2) It significantly reduced the nocturnal frequency, although that of daytime urination remained unchanged. 3) The drug significantly improved symptoms that existed before treatment. These results suggest that Saireito is effective for nocturia in patients with prostatic hyperplasia.