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タイトル: IL-2+IFN-α併用療法が著効した腎細胞癌肺転移の1例
その他のタイトル: Successful treatment for renal cell carcinoma with lung metastases by interleukin-2 and interferon-alfa: a case report
著者: 坂田, 裕子  KAKEN_name
小倉, 友二  KAKEN_name
脇田, 利明  KAKEN_name
林, 宣男  KAKEN_name
杉村, 芳樹  KAKEN_name
著者名の別形: Sakata, Yuko
Ogura, Yuji
Wakita, Toshiaki
Hayashi, Norio
Sugimura, Yoshiki
キーワード: Aged
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Carcinoma, Renal Cell/drug therapy/secondary/surgery
Combined Modality Therapy
Humans
Interferon-alpha/administration & dosage
Interleukin-2/administration & dosage
Kidney Neoplasms/drug therapy/pathology/surgery
Lung Neoplasms/drug therapy/secondary
Male
Nephrectomy
発行日: Jul-2003
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要
巻: 49
号: 7
開始ページ: 389
終了ページ: 391
抄録: 69歳男で, 右腎細胞癌(T2N0M1, stage IV)の摘出術後, 肺転移巣に対してIL-2(70万単位, 週5回静注)+IFN-α(600万単位, 週3回筋注)を8週間行い, 以後IL-2を週3回に減らして同様の治療を継続した.治療前のCTで転移巣は2cm大を示していたが, 1年後には索状陰影として認めるのみとなった
We report a case in which a regimen of interleukin-2 (IL-2) and interferon alfa (IFN-alpha) was effective against renal cell carcinoma with lung metastases. A 69-year-old man diagnosed with right renal tumor had not received treatment for 28 months. He was admitted to our hospital for treatment. Computed tomographic (CT) findings showed a right renal tumor 11.5 cm in diameter and multiple lung metastases. Right nephrectomy was performed, and pathological examination was renal cell carcinoma (clear cell carcinoma, G2, pT3a). A regimen of IL-2 and IFN-alpha was selected as an adjuvant therapy. He received 70 x 10(4) JRU/day of IL-2 (div) 5 times a week, and 600 x 10(4) IU/day of IFN-alpha intramuscularly 3 times a week for 8 weeks. Thereafter, both treatments were continued 3 times a week. CT scan showed a complete response on lung metastases 12 months and no recurrence has been observed on CT scan for 16 months after operation.
URI: http://hdl.handle.net/2433/115008
PubMed ID: 12968479
出現コレクション:Vol.49 No.7

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