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タイトル: | IL-2+IFN-α併用療法が著効した腎細胞癌肺転移の1例 |
その他のタイトル: | Successful treatment for renal cell carcinoma with lung metastases by interleukin-2 and interferon-alfa: a case report |
著者: | 坂田, 裕子 小倉, 友二 脇田, 利明 林, 宣男 杉村, 芳樹 |
著者名の別形: | Sakata, Yuko Ogura, Yuji Wakita, Toshiaki Hayashi, Norio Sugimura, Yoshiki |
キーワード: | Aged Antineoplastic Combined Chemotherapy Protocols/therapeutic use Carcinoma, Renal Cell/drug therapy/secondary/surgery Combined Modality Therapy Humans Interferon-alpha/administration & dosage Interleukin-2/administration & dosage Kidney Neoplasms/drug therapy/pathology/surgery Lung Neoplasms/drug therapy/secondary Male Nephrectomy |
発行日: | Jul-2003 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 49 |
号: | 7 |
開始ページ: | 389 |
終了ページ: | 391 |
抄録: | 69歳男で, 右腎細胞癌(T2N0M1, stage IV)の摘出術後, 肺転移巣に対してIL-2(70万単位, 週5回静注)+IFN-α(600万単位, 週3回筋注)を8週間行い, 以後IL-2を週3回に減らして同様の治療を継続した.治療前のCTで転移巣は2cm大を示していたが, 1年後には索状陰影として認めるのみとなった We report a case in which a regimen of interleukin-2 (IL-2) and interferon alfa (IFN-alpha) was effective against renal cell carcinoma with lung metastases. A 69-year-old man diagnosed with right renal tumor had not received treatment for 28 months. He was admitted to our hospital for treatment. Computed tomographic (CT) findings showed a right renal tumor 11.5 cm in diameter and multiple lung metastases. Right nephrectomy was performed, and pathological examination was renal cell carcinoma (clear cell carcinoma, G2, pT3a). A regimen of IL-2 and IFN-alpha was selected as an adjuvant therapy. He received 70 x 10(4) JRU/day of IL-2 (div) 5 times a week, and 600 x 10(4) IU/day of IFN-alpha intramuscularly 3 times a week for 8 weeks. Thereafter, both treatments were continued 3 times a week. CT scan showed a complete response on lung metastases 12 months and no recurrence has been observed on CT scan for 16 months after operation. |
URI: | http://hdl.handle.net/2433/115008 |
PubMed ID: | 12968479 |
出現コレクション: | Vol.49 No.7 |
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