前立腺肥大症に対する八味地黄丸少量2週間投与の治療成績

Abstract

前立腺肥大症に対する八味地黄丸の少量2週間投与による治療成績を検討した.対象は, 前立腺肥大症で前治療を受けていない41名(平均年齢65.2歳)で, 八味地黄丸エキス剤1日4.0gを2週間投与し, 塩酸タムスロシン0.2mg/日投与の70名(平均年齢66.9歳)をコントロールとして比較した.その結果, 自覚症状では尿勢低下および残尿量で, 国際前立腺スコア(I-PSS)の総スコア, 排尿症状サブスコア, QOLスコアで有意な改善を認めた.コントロールとの比較では主観的にI-PSS総スコアやQOLなどで塩酸タムスロシンの方が有意に良好であったが, 最大尿流量では八味丸で有意に改善度が高かった.また, 2つの治療効果判定基準の評価ではどちらの基準でも有効は約40%で, I-PSS, QOL, 機能のいずれかが有効な群では無効群に比し投薬前の残尿感スコアが有意に高く, QOLスコアが高い傾向が認められた.以上, 残尿感が主訴の患者には本薬剤がよい適応と考えられた

We evaluated the efficacy and side effects of two-week administration of low-dose "Hachimi-jio-gan (Ba-Wei Di-Huang-Wan)" for 41 patients with benign prostatic hyperplasia and searched for any predictors of good response to this agent. Although two of the 41 patients could not finish administration due to epigastric discomfort, there were no other side effects. "Hachimi-jio-gan" significantly reduced scores of emptying, weak stream, total score and quality of life score according to the International Prostate Symptom Score, although the degree of reduction was inferior to that induced by tamsulosin administration. "Hachimi-jio-gan" significantly improved max flow rate, and the degree of this improvement was superior to that induced by tamsulosin administration. Approximately 40% of patients were good responders to "Hachimi-jio-gan" therapy. Severe sensation of incomplete emptying was a predictor of good response.