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Title: 若年性浸潤性膀胱癌の1例
Other Titles: A case report of a young patient with invasive bladder cancer
Authors: 中嶋, 正和  KAKEN_name
西山, 博之  KAKEN_name
八木橋, 祐亮  KAKEN_name
山本, 新吾  KAKEN_name
賀本, 敏行  KAKEN_name
羽渕, 友則  KAKEN_name
小川, 修  kyouindb  KAKEN_id
Author's alias: Nakashima, Masakazu
Nishiyama, Hiroyuki
Yagihashi, Yusuke
Yamamoto, Shingo
Kamoto, Toshiyuki
Habuchi, Tomonori
Ogawa, Osamu
Keywords: Adult
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Carcinoma, Transitional Cell/drug therapy/pathology/surgery
Chemotherapy, Adjuvant
Cisplatin/administration & dosage
Epirubicin/administration & dosage
Methotrexate/administration & dosage
Neoplasm Invasiveness
Prostatic Neoplasms/pathology
Urinary Bladder Neoplasms/drug therapy/pathology/surgery
Urinary Diversion
Issue Date: Dec-2003
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 49
Issue: 12
Start page: 745
End page: 748
Abstract: 29歳男.肉眼的血尿と排尿時痛を自覚し受診,検尿にて膿尿を認め,出血性膀胱炎と診断された.排泄性尿路造影およびMRIを施行され,膀胱右壁に広基性腫瘤が認められ,浸潤性膀胱癌を疑われた.尿細胞診はclass V,CTおよびMRI上,膀胱右側壁から前立腺にかけて径6×3cmの腫瘤を認めた.膀胱鏡では膀胱右壁から前立腺にかかる単発の非乳頭状広基性腫瘤を認め,生検が行われた.なお,球部尿道に尿道狭窄を認め,尿道切開刀とYAGレーザーにて尿道切開術を施行した.病理学的検査で腫瘍が筋層内に浸潤増生する像を認め,移行上皮癌grade 3と診断した.また,右側前立腺内にも同様の異型細胞を認めており,T4aN0M0と診断した.妊孕性を考慮し,補助化学療法前に精子凍結保存を施行した後,術前化学療法としてMEG療法を3コース施行した.腫瘍はCT画像上消失したが,根治的膀胱全摘除術を施行した.病理組織学的検索では筋深層部に及ぶ分化度の低い移行上皮癌(G3)細胞をわずかに認め,pT2b pNOMOであった.術後18ヵ月,再発,転移は認められない
A 29-year-old male with bladder cancer was referred to our hospital. Histological examination of transurethral biopsy showed transitional cell carcinoma with invasion into prostate (T4aN0M0, grade 3). Nerve-sparing radical cystectomy with ileal neobladder reconstruction was performed after 3 courses of neoadjuvant chemotherapy with Methotrexate, Epirubicin and Cisplatin. Continence and erectile function were preserved and no recurrence has been observed for 18 months after the operation. This is the sixth case of an invasive bladder cancer in Japanese patients under 30 years old.
PubMed ID: 14978958
Appears in Collections:Vol.49 No.12

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