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dc.contributor.author松本, 成史ja
dc.contributor.author花井, 禎ja
dc.contributor.author栗田, 孝ja
dc.contributor.author秋山, 隆弘ja
dc.contributor.alternativeMatsumoto, Seijija
dc.contributor.alternativeHanai, Tadashija
dc.contributor.alternativeKurita, Takashija
dc.contributor.alternativeAkiyama, Takahiroja
dc.date.accessioned2010-05-27T07:26:12Z-
dc.date.available2010-05-27T07:26:12Z-
dc.date.issued2003-12ja
dc.identifier.issn0018-1994ja
dc.identifier.urihttp://hdl.handle.net/2433/115101-
dc.description.abstract1999~2000年までの2年間に膀胱疾患に対して手術加療され,膀胱の一部分,または全摘出した症例のうち,膀胱体部の標本を一部本研究に提供することに同意を得た15例(男11例,女4例,年齢7~82歳,平均52.1歳)を対象にした.基礎疾患は神経因性膀胱(NgB)2例,慢性腎不全6例,前立腺肥大症3例,膀胱癌(BT)3例,膀胱尿道逆流症1例であった.ヒト膀胱平滑筋細胞の形態学的phenotypeについて検討した結果,ヒト膀胱平滑筋細胞においても血管平滑筋細胞と同様にphenotypeという概念を用いて分類することが可能であった.膀胱において筋層内の線維化とphenotypeの比率に関連を認めなかった.また,NgBなどの病的膀胱には合成型phenotypeが優位で,収縮型から非収縮型へ膀胱平滑筋細胞のphenotypeが形質変換しており,このphenotypeの調節が排尿筋機能に重要な役割を果たしていると思われた.線維化や収縮能のマーカーと成り得る可能性が示唆されたja
dc.description.abstractTissue specimens were resected from 15 patients (age 7 to 82, average 52.2 years old) with bladder diseases; i.e., 2 with neurogenic bladder, 6 recipients of kidney transplantation with defunctionalized bladder, 3 with benign prostatic hypertrophy, 3 with bladder cancer and 1 with vesicoureteral reflux. We investigated the phenotypic expression of the bladder smooth muscle cells with bladder diseases. The ratio of non-contractile to contractile phenotypes (nc/c ratio) showed a rising tendency with aging. The increase of nc/c ratio was especially notable with neurogenic bladder. Phenotypic expression was observed in human bladder smooth muscle cells as reported in vascular smooth muscle cells. Several bladder diseases cause a conversion of contractile smooth muscle cell phenotype from contractile type to non-contractile type, and this modulation of smooth muscle cell phenotype may play an important role in detrusor function.ja
dc.format.mimetypeapplication/pdfja
dc.language.isojpnja
dc.publisher泌尿器科紀要刊行会ja
dc.subjectAdolescentja
dc.subjectAdultja
dc.subjectAgedja
dc.subjectAged, 80 and overja
dc.subjectChildja
dc.subjectContractile Proteins/metabolismja
dc.subjectFemaleja
dc.subjectHumansja
dc.subjectMaleja
dc.subjectMiddle Agedja
dc.subjectMuscle, Smooth/cytologyja
dc.subjectPhenotypeja
dc.subjectProstatic Hyperplasia/pathologyja
dc.subjectUrinary Bladder/cytologyja
dc.subjectUrinary Bladder Diseases/genetics/pathologyja
dc.subjectUrinary Bladder Neoplasms/pathologyja
dc.subjectUrinary Bladder, Neurogenic/pathologyja
dc.subject.ndc494.9ja
dc.titleヒト膀胱平滑筋細胞の形態学的Phenotypeの検討ja
dc.title.alternativePhenotypic changes in human bladder smooth muscle cellja
dc.type.niitypeDepartmental Bulletin Paperja
dc.identifier.ncidAN00208315ja
dc.identifier.jtitle泌尿器科紀要ja
dc.identifier.volume49ja
dc.identifier.issue12ja
dc.identifier.spage715ja
dc.identifier.epage719ja
dc.textversionpublisherja
dc.sortkey02ja
dc.address近畿大学 医学部泌尿器科ja
dc.address.alternativeDepartment of Urology, Kinki University School of Medicine.ja
dc.identifier.pmid14978953ja
Appears in Collections:Vol.49 No.12

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