腎細胞癌における臨床的および病理学的因子と予後の関連

Abstract

病理組織学的に腎細胞癌と確認された42例を対象に, 生存に影響を与える因子を検討した。1)clinical stage, 術前の発熱の有無, α2-gl., CRP, 血沈値の上昇, 組織学的異形度, 浸潤形式等の因子が生存に有意に影響を与えた。2)偶発19例は症状を有した23例に較べて生存率が高い傾向がみられた。3)術前の腎動脈塞栓術は生存率を向上しえなかった。術後のIFNα投与の有無による生存率の差はなかった

The clinical, pathological and survival data were analyzed for 42 patients with nephrectomy for renal cell carcinoma, who visited our department between 1987 and 1992. The factors influencing prognosis were evaluated. There were 33 males and 9 females with an average age of 59.1 years old. Forty-five percent (19 patients) of the cases were detected incidentally. These incidental cases showed a higher survival rate than the cases with symptoms although the difference was not statistically significant. Positive acute phase reactant, clinical stage, grade and type of infiltration were to be considerably predictive factors indicating poor prognosis. Embolization of renal artery for neo -adjuvant therapy could not improve the survival rate. Interferon-alpha for adjuvant therapy did not prolong the survival team clearly.