パラコート中毒に対する血液吸着および血漿交換療法による治療経験

Abstract

除草剤パラコート(P)を自殺目的で服毒した5症例に対して, DHP単独治療を3例に, DHPとDFPPの併用療法を2例に施行し, DHP単独治療の3例中2例を救命しえた。血中P濃度値がProudfootらの生存可能曲線を越える症例では, DHPの単独治療ではなくHD・HF・DFPPを適切に組み合わせた治療がより有効と考えられた

In these past three years, we treated 5 patients who attempted suicide by taking paraquat, a herbicide that had been kept at home, by direct hemoperfusion (DHP) alone or in combination with double filtration plasmapheresis (DFPP) in addition to conservative therapy. DHP alone was performed on 3 patients, 2 of whom recovered. The other 1 patient treated by DHP alone and 2 treated by the combination therapy died. These patients showed a plasma paraquat concentration exceeding the survival curve presented by Proudfoot. In such patients, appropriate combinations among hemodialysis, hemofiltration, DHP, and DFPP may be safer and more effective than each therapy alone.