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Title: 癌性髄膜炎をきたした膀胱移行上皮癌の1例
Other Titles: A case of carcinomatous meningitis from transitional cell carcinoma of the urinary bladder
Authors: 原, 暢助  KAKEN_name
小林, 裕  KAKEN_name
後藤, 健太郎  KAKEN_name
戸塚, 一彦  KAKEN_name
徳江, 章彦  KAKEN_name
望月, 真  KAKEN_name
Author's alias: Hara, Yosuke
Kobayashi, Yutaka
Goto, Kentaro
Tozuka, Kazuhiko
Tokue, Akihiko
Mochizuki, Makoto
Keywords: Bladder cancer
Carcinomatous meningitis
Issue Date: Dec-1994
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 40
Issue: 12
Start page: 1113
End page: 1117
Abstract: We report a case of carcinomatous meningitis from transitional cell carcinoma of the urinary bladder. A 70-year-old man with invasive bladder cancer and multiple pulmonary metastases received 3 courses of systemic M-VAC (methotrexate, vinblastine, doxorubicin, and cisplatin) chemotherapy, after which the primary tumor and pulmonary metastases diminished in size and number. During the 4th course of chemotherapy, he complained of nausea, headache, diplopia, and neck stiffness. Computer tomographic (CT) scan of the brain showed no evidence of parenchymal metastases, cerebral hemorrhage, or infarction. Cerebrospinal fluid examination revealed an increase in cells along with elevated protein and depressed glucose concentrations, but no malignant cells were identified. He died two weeks after the onset of neurological symptoms. Autopsy revealed numerous tiny metastatic lesions in the leptomeninx, so called carcinomatous meningitis, without parenchymal metastases in the brain. Although metastases to the central nervous system from transitional cell carcinoma of the bladder, especially carcinomatous meningitis rarely have been reported, this unusual complication will be seen more frequently with the development of more effective systemic chemotherapy such as M-VAC.
PubMed ID: 7863865
Appears in Collections:Vol.40 No.12

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