Access count of this item: 232
|Other Titles:||Study on E-cadherin expression in relation to invasion and metastasis in urothelial cancer patients|
|Authors:||川喜田, 睦司 |
|Author's alias:||Kawakita, Mutsushi|
|Abstract:||尿路上皮癌30例について検討した。E-カドヘリンの発現が減弱しているものは全例grade 2以上でpT 2以上が75%を占め,high grade, high stageが有意に多く,今後予後因子のひとつとなる可能性がある|
E-cadherin expression was investigated in 30 patients with urothelial cancer (bladder; 27, ureter; 2, urethra; 1) by an immunohistochemical method. Twelve out of 22 patients with strong and homogeneous expression of E-cadherin (preserved) had grade 1 tumors, while all 8 patients with heterogeneous, weak and homogeneous, or lost expression of E-cadherin (reduced) had grade 2 or grade 3 tumors. Only 2 out of 22 patients with preserved expression had invasive tumors (> or = pT2), whereas 6 out of 8 patients with reduced expression had invasive tumors (p = 0.002). Three out of 4 patients with metastasis had reduced expression and 2 of them died. These findings suggest that urothelial tumors with reduced expression of E-cadherin have high grade and high stage, and E-cadherin expression could be one of the prognostic factors.
|Appears in Collections:||Vol.40 No.12|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.