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Title: 尿路上皮癌におけるE-カドヘリンの発現と浸潤・転移の検討
Other Titles: Study on E-cadherin expression in relation to invasion and metastasis in urothelial cancer patients
Authors: 川喜田, 睦司  KAKEN_name
諸井, 誠司  KAKEN_name
京谷, 京子  KAKEN_name
筧, 善行  KAKEN_name
吉田, 修  KAKEN_name
Author's alias: Kawakita, Mutsushi
Moroi, Seiji
Kyotani, Kyoko
Kakehi, Yoshiyuki
Yoshida, Osamu
Keywords: E-cadherin
Adhesion molecule
Urothelial cancer
Bladder cancer
Issue Date: Dec-1994
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 40
Issue: 12
Start page: 1077
End page: 1080
Abstract: 尿路上皮癌30例について検討した。E-カドヘリンの発現が減弱しているものは全例grade 2以上でpT 2以上が75%を占め,high grade, high stageが有意に多く,今後予後因子のひとつとなる可能性がある
E-cadherin expression was investigated in 30 patients with urothelial cancer (bladder; 27, ureter; 2, urethra; 1) by an immunohistochemical method. Twelve out of 22 patients with strong and homogeneous expression of E-cadherin (preserved) had grade 1 tumors, while all 8 patients with heterogeneous, weak and homogeneous, or lost expression of E-cadherin (reduced) had grade 2 or grade 3 tumors. Only 2 out of 22 patients with preserved expression had invasive tumors (> or = pT2), whereas 6 out of 8 patients with reduced expression had invasive tumors (p = 0.002). Three out of 4 patients with metastasis had reduced expression and 2 of them died. These findings suggest that urothelial tumors with reduced expression of E-cadherin have high grade and high stage, and E-cadherin expression could be one of the prognostic factors.
PubMed ID: 7863859
Appears in Collections:Vol.40 No.12

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