淋菌に対する最小発育阻止濃度の経年的変化

Abstract

1983～1991年の間に日本赤十字社医療センター泌尿器科で分離培養された淋菌465株に就いて検討した。9年間のPPNG(ペニシリナーゼ産生淋菌)の年次頻度は3～17%で, 増加傾向は認めなかった。ペニシリンGに関しては, PPNGのMIC(最小発育阻止濃度)90値は非PPNGのそれに比し7倍以上高かった。セフェム, テトラサイクリン, 及びニューキノロンのMIC 90値はPPNGと非PPNGとの間で著差がなかった。ペニシリンG, セフェム, 及びスペクチノマイシンのMICの年次差異は認められなかったが, ニューキノロンでは上昇傾向が見られた

Between 1983 and 1991, 465 gonococcal strains isolated in the urological department of Japanese Red Cross Medical Center. The minimum inhibitory concentration (MIC) of these isolates to 22 kinds of antibiotics including penicillins (PC), cephems, tetracyclins (TC) and new quinolons (NQ) were determined and the annual difference of MIC was studied. The annual incidence of penicillinase producing neisseria gonorrhoeae (PPNG) of these 9 years were distributed in 3 to 17% and increasing tendency was not observed. As for Penicillin G, the MIC 90 of PPNG was seven fold higher than that of non-PPNG. No remarked difference was observed between MIC 90 of Cephems, TC and NQ of PPNG and non-PPNG. No annual difference was observed in MIC of PC, Cephems and SPCM. However the rising tendency of MIC was observed in NQ.