上部尿路結石症の家族集積性における遺伝要因の検討

Abstract

上部尿路結石症の家族集積性について, アンケート調査方式を用いて対照群と比較検討した. 1)結石患者群は対照群に比べ高率に家族集積性を有しており, 発症時非同居症例においても同様であった. 2)結石患者の性別での比較では有意差を認めなかった. 3)再発結石患者は初発患者に比べて高い家族集積性を有しており, 対照群との比較でも配偶者を除き他の家族すべてにおいて有意に家族集積性を認めた. 4)家族集積性に対して近親婚の影響があるとはいえなかった

The family history between patients with upper urinary tract stones and healthy subjects was compared to evaluate the possible involvement of genetic factors in obtaining information through a questionnaire. The patients showed a significantly more marked history than the healthy subjects (p < 0.001). In particular, recurrent stone formers showed a significantly more marked history than single stone formers (p < 0.05). Compared with the healthy subjects, a more marked family history was observed in the parents, brothers and sisters, and children, but not in the spouse (p < 0.05-0.005). However, the family history was not affected by consanguineous marriage. A more marked family history was observed in patients with upper urinary tract stones, suggesting the involvement of genetic factors in the development of upper urinary tract stones. In particular, genetic factors seem to be more closely involved in recurrent stone formers.