Snell下垂体性小人症マウスにおける成長ホルモン, 甲状腺ホルモンの腎発育への影響

Abstract

Snell下垂体性小人症マウスを用い, 腎臓の成長過程におよぼすGH, T4の効果を生化学的, 組織学的に検討した.GH, T4欠損による腎組織の発育障害は10日齢から20日齢の間に顕著となるが, すでに10日齢前後より発育障害が始まっていると推察された

To elucidate the effects of growth hormone (GH) and thyroxine (T4) on renal development, we biochemically and morphologically examined the renal tissue of Snell pituitary dwarf mice (dw/dw) at different developmental stages. Differences in DNA, RNA and insulin-like growth factor-1 (IGF-1) content between the dwarf and normal control mice first became apparent on the 10th day of age, and from this time that of dwarf mice showed no further increase in DNA and RNA content and decrease in IGF-1 content, whereas that of the normal control mice continued to increase. These findings indicated that GH and T4 may have effects on the renal development, and deficiency of these hormones to affect renal development from the 10th day of age.