ダウンロード数: 273
タイトル: | 腎癌肺転移にInterferon-α, 5-Fluorouracil,ロイコボリン併用療法を行った3例 |
その他のタイトル: | Three cases of lung metastases of renal cell carcinoma treated with a combination of interferon-alpha, 5-fluorouracil and leucovorin |
著者: | 富樫, 正樹 田端, 哲也 平川, 和志 大橋, 伸生 新藤, 純理 平野, 哲夫 出村, 孝義 |
著者名の別形: | TOGASHI, Masaki TABATA, Tetsuya HIRAKAWA, Kazushi OHASHI, Nobuo SINDOH, Jyunri HIRANO, Tetsuo DEMURA, Takayoshi |
キーワード: | Renal cell carcinoma Biochemical modulation |
発行日: | Jan-1996 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 42 |
号: | 1 |
開始ページ: | 43 |
終了ページ: | 45 |
抄録: | 腎癌肺転移の3例(64歳男, 66歳男, 60歳男)に対し, BCMの概念に基づいたIFNα, 5-FU及びLVを用いた3剤併用療法を行った.1例でCR, 2例でstable diseaseの結果をえた.主な副作用は口内炎, 下痢であり, 1例で5-FU投与を中止したが, 2例では継続治療可能であった Three patients with lung metastases of renal cell carcinoma (RCC) were treated with a combination of interferon-alpha, leucovorin and 5-fluorouracil. All patients were male between 60 and 66 years and had been treated by nephrectomy prior to the combination therapy. Interferon-alpha was administered at the dose of 9 x 10(6) IU intramuscularly 3 times/week, leucovorin at 30 mg/m2 per day intravenously (day 1 to 5) and 5-fluorouracil at 500 mg/m2 daily by continuous infusion intravenously (day 1 to 5) followed by weekly bolus therapy. One patient achieved complete response for 17 months and the other two achieved stable disease for 6 and 16 months. Side effects related to this therapy were diarrhea, stomatitis, alopecia, leucocytopenia and thrombocytopenia. Grade 3 stomatitis occurred after the continuous administration of 5-fluorouracil in one patient; he recovered by discontinuation of 5-fluorouracil. Combination therapy with interferon-alpha, leucovolin and 5-fluorouracil might be effective for the treatment of lung metastases of RCC. |
URI: | http://hdl.handle.net/2433/115653 |
PubMed ID: | 8686582 |
出現コレクション: | Vol.42 No.1 |
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