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タイトル: | 腎細胞癌の腫瘍内浸潤リンパ球におよぼす遺伝子組換えインターフェロンγの影響 : 臨床病期との関連性について |
その他のタイトル: | Immunological effect of recombinant interferon-gamma on tumor infiltrating lymphocytes of renal cell carcinoma--relationship with clinical stage |
著者: | 川田, 望 滝本, 至得 平野, 大作 山本, 忠男 平方, 仁 山中, 弥太郎 岡田, 安弘 千野, 健志 杉本, 周路 五十嵐, 匠 |
著者名の別形: | KAWATA, Nozomu TAKIMOTO, Yukie HIRANO, Daisaku YAMAMOTO, Tadao HIRAKATA, Hitoshi YAMANAKA, Yataro OKADA, Yasuhiro CHINO, Kenji SUGIMOTO, Shuji IGARASHI, Takumi |
キーワード: | Renal cell carcinoma Tumor infiltrating lymphocytes Interferon-y Clinical stage |
発行日: | Jan-1996 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 42 |
号: | 1 |
開始ページ: | 1 |
終了ページ: | 4 |
抄録: | 1)腎細胞癌例を対象として, 術前にIFN-γを投与した投与群と無投与群で比べると, 投与群でCD3, CD8, CD11b, ICAM-1が有意に多く認められた. 2)High stageの例で無投与群に比べ, CD3, CD8, CD11b, ICAM-1が投与群に有意に多く認められた We studied the relationship between clinical stage and tumor infiltrating lymphocytes (TIL) in 26 cases of renal cell carcinoma. In 10 patients, interferon-gamma (IFN-gamma) was administered preoperatively (administration group); 5 patients had low stage (Robson or = II) tumors. The other 16 patients underwent nephrectomy alone without preoperative IFN administration (control group); 11 patients had low stage, and the remaining 5 patients had high stage tumors. Immunohistochemical studies of tumor infiltrating lymphocytes in renal cell carcinoma showed a significantly high incidence of CD3, CD8, CD11b and ICAM-1 in the administration group, while CD4, LFA-1 and Ber-MAC3 were increased without significance (p < 0.05). Concerning clinical stage (Robson), a significant increase in CD3, CD8, CD11b and ICAM-1 was observed in the patients with high-stage tumors in the administration group compared to those in the control group (p < 0.05). This suggested that TIL could be changed by preoperative administration of IFN-gamma. |
URI: | http://hdl.handle.net/2433/115661 |
PubMed ID: | 8686575 |
出現コレクション: | Vol.42 No.1 |
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