Ta膀胱腫瘍のStage-up例におけるp53蛋白の免疫組織化学的検討

Abstract

Stage-up症例の経過中, p53蛋白は浸潤癌(T1以上)になった時点で初めて陽性となった.この結果からp53遺伝子の変異と表在性膀胱腫瘍のstage-upの関係が示唆された.一方, 進達度TaやTISの表在性膀胱腫瘍でp53 overexpressionは検出されず, 今回の検討では表在性膀胱腫瘍のstage-upをp53overexpressionを用いて予見することはできなかった

To evaluate the significance of p53 overexpression on the progression of bladder cancer, seven patients with Ta bladder cancer who eventually progressed to the invasive stage ( > or = stage T1) were immunohistochemically analyzed. The immunohistochemical study was performed using the p53 protein antibody on formalin-fixed, paraffin-embedded tissue sections from all primary and recurrent tumors. In three patients, immunoreactivity was detected only at the time of disease progression, suggesting that p53 mutation may be related to the disease. However, since no staining could not be found in stage Ta bladder cancer, the patient with a risk of progression could not be detected by this immunohistochemical study.