膀胱Inverted papilloma 9例の臨床的検討

Abstract

1)手術を施行した膀胱腫瘍症例は204例で, inverted papillomaは全体の4.5%. 2)9例のうち1年以上の経過観察可能7症例の平均観察期間は26.6ヵ月, 再発を認めた症例はなかった. 3)肉眼的腫瘍形態では, 茎が太く短いものは全例腫瘍表面が平滑で(A), 逆に茎が細く長いものには表面が一部乳頭状のものが含まれた(B).前者(A)は殆どが膀胱三角部に発生し, 後者(B)は全例膀胱頸部に発生していた. 4)病理組織学的にはtrabecular typeが5例でglandular typeが4例であった.抗PSA抗体による免疫組織染色では発生部位, 肉眼的腫瘍形態及び組織学的分類に関わらず, いずれの症例も染色されなかった

Clinical studies were conducted on 9 cases of inverted papilloma of the urinary bladder which were transurethrally resected between August, 1987 and July, 1995 at our hospital, in males between 29 and 81 years of age (mean:58.3). Six of the 9 inverted papillomas were localized at the bladder neck and 3 in the trigone. Cystoscopic examinations revealed that inverted papillomas were divided into two types, one with a thick and short stalk with a smooth surface and the other with a thin and long stalk with/without a partial papillary surface. The majority of the former was located in the trigone and all of the latter cases in the bladder neck, suggesting that the two types occurred at different sites. Pathological examination by Hematoxylin-Eosin staining demonstrated that 5 of the 9 cases were of the trabecular type and 4 were of the grandlar type. Immunohistochemically, none of the tumors were stained with the antiprostatic-specific-antigen antibody revealed. Follow-up periods after the operation were from 12 to 48 months(mean:26.6 months) and no recurrence was observed.