腎盂尿管癌の予後規定因子の検討 : 平均核容積の有用性について

Abstract

1)腎盂尿管癌において, MNVのみが生存率と有意に相関し, 年齢, 筋層浸潤とは有意な関係は認められなかった.gradeに関しては結論に至らなかった. 2)腎盂尿管癌においてもMNVは予後規定の重要な因子であると示唆された

A retrospective, prognostic study was performed on 22 patients with transitional cell carcinoma of the upper urinary tract seen between Dec. 1982 and Jun. 1995. Unbiased estimates of volume weighted mean nuclear volume (MNV) were compared with age at the time of diagnosis, muscle invasion, and histological grading according to World Health Organization (WHO) classification on the prognostic value. Estimates of MNV were significantly correlated (p = 0.0135) only with disease-specific survival of transitional cell carcinoma of the upper urinary tract, contrary to age at the time of diagnosis (p = 0.4865), and muscle invasiveness (p = 0.1756). The analysis was not conclusive with regard to the WHO classification as the prognostic factor in this study. Estimates of MNV also were significantly correlated (p = 0.0325) with disease-specific survival in patients diagnosed histologically as grade 2. These findings indicate that estimates of MNV are useful for determining the prognosis of transitional cell carcinoma of the upper urinary tract.