イヌ生体位膀胱機能に対する牛車腎気丸の作用

Abstract

牛車腎気丸のイヌ生体位膀胱機能に対する作用について検討した. 1)律動的膀胱収縮では牛車腎気丸投与により収縮の抑制と収縮振幅の低下がみられた. 2)膀胱内圧測定による排尿反射の観察では牛車腎気丸投与により最大膀胱容量の増加傾向が見られ, 排尿閾値圧の低下はなかった

Gosha-Jinki-Gan is clinically used for the treatment of pollakiuria in patients with benign prostatic hyperplasia. The effect of Gosha-Jinki-Gan on the function of the urinary bladder in anesthetized dogs was examined. Gosha-Jinki-Gan (100 mg/kg) inhibited the rhythmic bladder contractions (RBC). However, the frequency of RBC increased resembling the effect of atropine (0.1 mg/body), and the amplitude decreased. On the cystometrogram, Gosha-Jinki-Gan caused an increase in maximum vesical volume (not significant). These findings indicated that Gosha-Jinki-Gan is a useful drug for the treatment of pollakiuria.