原発性限局性膀胱アミロイドーシスの1例

Abstract

肉眼的血尿を訴えた57歳男で, 膀胱鏡検査は前壁から右側壁に亙る広基性腫瘤性病変を示した.膀胱腫瘍を疑い, 経尿道的切除を行った所, 組織学的にアミロイド沈着を認めたが, 悪性変化はなかった.血清電気泳動パターンは正常で, 尿中Bence-Jones蛋白は陰性であった.直腸及び胃生検ではアミロイドを認めなかった.以上より原発性限局性膀胱アミロイドーシスと診断した

A case of primary localized amyloidosis of the urinary bladder is reported. A 57-year-old male who complained of macrohematuria visited our hospital. Cystoscopic examination revealed a broad basic tumor from the anterior wall to the right wall. Suspecting a bladder tumor we performed a transurethral resection. However, the histopathological examination of the specimen revealed amyloid deposition and no malignant changes. Serum electrophoresis pattern was normal and urinary Bence-Jones protein was negative. Neither rectal nor gastric biopsy revealed amyloids. From these findings, we made a diagnosis of the primary localized amyloidosis of the urinary bladder. We collected 42 cases from the Japanese literature and discuss the clinical features of this disease.