塗銀抗菌性尿道留置カテーテル(ウロトピックAgプロテイン)の長期留置におけるカテーテル表面の電子顕微鏡的検討

Abstract

塗銀抗菌性カテーテルの長期留置における安全性を4週間以上留置可能な8例で検討し, カテーテル表面の付着物を走査型電子顕微鏡で観察した.尿路感染を有する5例で, カテーテル表面の付着物をシリコンカテーテルと比較検討した. 1)全例において塗銀抗菌性カテーテルの長期留置が可能であり, 長期留置に起因する弊害を認めなかった. 2)比較可能であった4例において, 細菌の付着はシリコンカテーテルの全例に認められたが, 塗銀抗菌性カテーテルでは認めなかった. 3)結晶の形成は両者は同程度であったが, 全てのカテーテルの通過性は良好であった

In order to determine the bacterial and crystal adherence to long-term indwelling urethral catheters, we performed a scanning electron microscopic study utilizing commercially available silver-protein-coated latex (Urotopic Ag Protein) and silicone urethral catheters that were left in place for over 4 weeks. Microorganisms and crystals frequently were associated with fibrillar materials. On the surface of silicone catheters bacteria often were embedded in the amorphous matrix. In contrast we found no bacteria adhering to the antimicrobial urethral catheter surface coated with silver-protein. Crystal formation was similar in both catheters, but no catheteral obstruction was observed in this study. We suggested that antimicrobial urethral catheter coated with silver-protein is applicable to patients who tend to form encrustations on long-term indwelling catheters.