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dc.contributor.author | 橋村, 孝幸 | ja |
dc.contributor.author | 上田, 朋宏 | ja |
dc.contributor.author | 日裏, 勝 | ja |
dc.contributor.author | 吉田, 修 | ja |
dc.contributor.author | 川端, 健二 | ja |
dc.contributor.author | 渡部, 好彦 | ja |
dc.contributor.author | 高見, 昌史 | ja |
dc.contributor.alternative | HASHIMURA, Takayuki | en |
dc.contributor.alternative | UEDA, Tomohiro | en |
dc.contributor.alternative | HIURA, Masaru | en |
dc.contributor.alternative | YOSHIDA, Osamu | en |
dc.contributor.alternative | KAWABATA, Kenji | en |
dc.contributor.alternative | WATANABE, Yoshihiko | en |
dc.contributor.alternative | TAKAMI, Masashi | en |
dc.date.accessioned | 2010-05-28T06:15:10Z | - |
dc.date.available | 2010-05-28T06:15:10Z | - |
dc.date.issued | 1997-11 | - |
dc.identifier.issn | 0018-1994 | - |
dc.identifier.uri | http://hdl.handle.net/2433/116064 | - |
dc.description.abstract | 遺伝子治療の基礎的実験として, マウス膀胱癌細胞株MBT2の移植腫瘍に対して, IFN-γの全身投与と, 腫瘍へのIFN-γ遺伝子導入により抗腫瘍効果が異なるかを検討した. 1)マウス膀胱癌MBT2移植腫瘍に対してIFN-γを皮下注或いは腹腔内投与した.腫瘍形成の抑制, 生存期間の延長は認められず, IFN-γの全身投与の有意な抗腫瘍効果はなかった. 2)マウス膀胱癌MBT2移植腫瘍に対してIFN-γ遺伝子を腫瘍に導入した.腫瘍形成の抑制, 生存期間の延長が認められ, IFN-γ遺伝子の腫瘍細胞への導入により有意な抗腫瘍効果が認められた | ja |
dc.description.abstract | For the clinical application of the cytokine gene therapy, the antitumor effects of systemic administration of Interferon-gamma (IFN-gamma) and those of in vivo direct IFN-gamma gene transfer to the tumors of mouse bladder carcinoma (MBT2) were compared. After the subcutaneous inoculation of MBT2 cells into mice, 10(2), 10(3) or 10(4) units of IFN-gamma were injected intraperitoneally (i.p.) or subcutaneously (s.c.). Neither i.p. nor s.c. injection of IFN-gamma resulted in tumor suppression or prolonged the survival time of tumor-bearing mice. The effect of in vivo direct IFN-gamma gene transfer by a retrovirus vector to MBT2 tumors was also evaluated. After the subcutaneous inoculation of MBT2 cells into mice, a virus culture supernatant containing IFN-gamma gene was injected into the same tumor site once a day for 3 days. In 50% of the mice in the treatment groups with IFN-gamma gene induction, no tumor formation was observed. Tumor-free survival and actuarial survival in the treatment groups were significantly longer than those in the control group. These results showed the possibility of in vivo direct IFN-gamma gene transfer into tumors and were encouraging for the execution of tumor cell-targeted IFN-gamma gene therapy against human bladder cancer. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | jpn | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.subject | IFN-γ | en |
dc.subject | Gene therapy | en |
dc.subject | Bladder cancer | en |
dc.subject | MBT2 | en |
dc.subject | Immunotherapy | en |
dc.subject.ndc | 494.9 | - |
dc.title | 膀胱癌細胞へのin vivoにおけるInterferon-γ遺伝子導入による遺伝子治療 | ja |
dc.title.alternative | Gene therapy by in vivo interferon-gamma gene transfer to murine bladder tumor | en |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 43 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 809 | - |
dc.identifier.epage | 813 | - |
dc.textversion | publisher | - |
dc.sortkey | 10 | - |
dc.address | 京都大学医学部泌尿器科学教室 | ja |
dc.address | 京都大学医学部泌尿器科学教室 | ja |
dc.address | 京都大学医学部泌尿器科学教室 | ja |
dc.address | 京都大学医学部泌尿器科学教室 | ja |
dc.address | 京都大学薬学部薬剤学教室 | ja |
dc.address | 京都大学薬学部微生物薬品学教室 | ja |
dc.address | 国立京都病院臨床研究部 | ja |
dc.address.alternative | the Department of Urology, Faculty of Medicine, Kyoto University | en |
dc.address.alternative | the Department of Urology, Faculty of Medicine, Kyoto University | en |
dc.address.alternative | the Department of Urology, Faculty of Medicine, Kyoto University | en |
dc.address.alternative | the Department of Urology, Faculty of Medicine, Kyoto University | en |
dc.address.alternative | the Department of Drug Delivery Research, the Faculty of Pharmaceutical Sciences, Kyoto University | en |
dc.address.alternative | the Department of Molecular Microbiology, Faculty of Pharmaceutical Sciences, Kyoto University | en |
dc.address.alternative | the Department of Clinical Research, Kyoto National Hospital | en |
dc.identifier.pmid | 9436027 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.43 No.11 |
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