Chromophobe cell renal carcinomaの1例

Abstract

無症候性肉眼的血尿を訴えた59歳女で, 腹部CTは左腎に約4cmの少し増強される腫瘤, 血管造影は左腎に血管過小腫瘤, をそれぞれ描出した.腎細胞癌の診断で根治的左腎摘除術を行った.肉眼的に腫瘍の割面はベージュ色で, 少数の出血・壊死巣を持っていた.組織学的に腫瘍は通常のヘマトキシリン-エオジンで軽く染色される容量の大きい網状細胞質を持つ細胞より成っていた.Haleのコロイド鉄染色は陽性細胞質反応を示した.病理診断は嫌色素性細胞腎癌であった

We report a case of chromophobe cell renal carcinoma. A 59-year-old female was admitted to our hospital with asymptomatic gross hematuria. Abdominal computerized tomography showed an approximately 4 cm. minimally enhancing mass in the left kidney. Angiography revealed a hypovascular tumor in the left kidney. Under the diagnosis of renal cell carcinoma, left radical nephrectomy was performed. The cut surface of the tumor was beige in color with few foci of hemorrhage and necrosis. Microscopically, the tumor was composed of the cells with voluminous reticulated cytoplasm stained lightly with routine hematoxylin and eosin. Hale's colloidal iron staining demonstrated a positive cytoplasmic reaction. Pathological diagnosis was chromophobe cell renal carcinoma. Chromophobe cell renal carcinoma is a recently established subtype of renal cell carcinoma, which has rarely been reported in Japan.