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dc.contributor.author三木, 恒治ja
dc.contributor.author野々村, 祝夫ja
dc.contributor.author児島, 康行ja
dc.contributor.author奥山, 明彦ja
dc.contributor.author中野, 悦次ja
dc.contributor.author藤岡, 秀樹ja
dc.contributor.author若月, 晶ja
dc.contributor.author菅尾, 英木ja
dc.contributor.author竹山, 政美ja
dc.contributor.author清原, 久和ja
dc.contributor.author小出, 卓生ja
dc.contributor.author黒田, 秀也ja
dc.contributor.author瀬口, 利信ja
dc.contributor.author山口, 誓司ja
dc.contributor.alternativeMIKI, Tsuneharuja
dc.contributor.alternativeNONOMURA, Norioja
dc.contributor.alternativeKOJIMA, Yasuyukija
dc.contributor.alternativeOKUYAMA, Akihikoja
dc.contributor.alternativeNAKANO, Etsujija
dc.contributor.alternativeFUJIOKA, Hidekija
dc.contributor.alternativeWAKATSUKI, Akiraja
dc.contributor.alternativeSUGAO, Hidekija
dc.contributor.alternativeTAKEYAMA, Masamija
dc.contributor.alternativeKIYOHARA, Hisakazuja
dc.contributor.alternativeKOIDE, Takuoja
dc.contributor.alternativeKURODA, Hideyaja
dc.contributor.alternativeSEGUTI, Toshinobuja
dc.contributor.alternativeYAMAGUCHI, Seijija
dc.date.accessioned2010-05-28T06:15:38Z-
dc.date.available2010-05-28T06:15:38Z-
dc.date.issued1997-12ja
dc.identifier.issn0018-1994ja
dc.identifier.urihttp://hdl.handle.net/2433/116080-
dc.description.abstractTHP膀胱内注入療法は,対照群に比べdisease free intervalの延長は認めなかったが,初発症例群或いは多発症例群において有意の再発予防効果を認めた.副作用において臨床的に問題となるものは膀胱刺激症状であり,その他特に重篤な副作用はなかったja
dc.description.abstractA prospective randomized study was conducted to evaluate the efficacy of prophylactic intravesical instillation of tetrahydropyranyladriamycin (THP) following complete transurethral resection (TUR) of superficial bladder cancer. A total of 80 patients were randomized into "THP" or "control" group. In the THP group, 20 mg of THP dissolved in 40 ml saline (or 5% dextrose) was administered intravesically once a week for 10 weeks, starting from about 7 days after TUR. In the control group, 40 ml saline was given with the same schedule. The patients were followed up by cystoscopy and urinary cytology every 3 months. The number of evaluable patients was 36 for the THP group and 37 for the control group. The non-recurrence rates in the THP group and control group were 79.4% versus 63.2% at 1 year and 69.8% versus 47.4% at 3 to 5 years, respectively. These figures were not statistically significant. However, THP instillation significantly reduced tumor recurrence rates for multiple tumors, and also tended to decrease recurrence rates for primary and pT1 tumors. Adverse effects were observed in 53.6% of the patients in the THP group, but they were tolerable. Our results suggest that intravesical THP instillation would not be effective for all patients with superficial bladder cancer. Further study is warranted in a selected group of patients.ja
dc.format.mimetypeapplication/pdfja
dc.language.isojpnja
dc.publisher泌尿器科紀要刊行会ja
dc.subjectBladdercancerja
dc.subjectBladderinstillationtherapyja
dc.subjectTHP(tetrahydropyranyladriamycin)ja
dc.subject.ndc494.9ja
dc.title表在性膀胱腫瘍に対する塩酸ピラルビシン(THP)の膀胱内注入による長期再発予防効果ja
dc.title.alternativeA randomized study on intravesical pirarubicin (THP) chemoprophylaxis of recurrence after transurethral resection of superficial bladder cancerja
dc.type.niitypeDepartmental Bulletin Paperja
dc.identifier.ncidAN00208315ja
dc.identifier.jtitle泌尿器科紀要ja
dc.identifier.volume43ja
dc.identifier.issue12ja
dc.identifier.spage907ja
dc.identifier.epage912ja
dc.textversionpublisherja
dc.sortkey14ja
dc.address大阪大学医学部泌尿器科学教室ja
dc.address大阪大学医学部泌尿器科学教室ja
dc.address大阪大学医学部泌尿器科学教室ja
dc.address大阪大学医学部泌尿器科学教室ja
dc.address中野クリニックja
dc.address大阪警察病院泌尿器科ja
dc.address近畿中央病院泌尿器科ja
dc.address箕面市立病院泌尿器科ja
dc.address大阪中央病院泌尿器科ja
dc.address市立豊中病院泌尿器科ja
dc.address大阪厚生年金病院泌尿器科ja
dc.address大手前病院泌尿器科ja
dc.address小松病院泌尿器科ja
dc.address市立池田病院泌尿器科ja
dc.address.alternativethe Department of Urology, Osaka University Medical Schoolja
dc.address.alternativethe Department of Urology, Osaka University Medical Schoolja
dc.address.alternativethe Department of Urology, Osaka University Medical Schoolja
dc.address.alternativethe Department of Urology, Osaka University Medical Schoolja
dc.address.alternativethe Nakano Clinicja
dc.address.alternativethe Department of Urology, Toyonaka Municipal Hospitalja
dc.address.alternativethe Department of Urology, Osaka Police Hospitalja
dc.address.alternativethe Department of Urology, Kinki Central Hospitalja
dc.address.alternativethe Department of Urology, Mino City Hospitalja
dc.address.alternativethe Department of Urology, Osaka Central Hospitalja
dc.address.alternativethe Department of Urology, Osaka Koseinenkin Hospitalja
dc.address.alternativethe Department of Urology, Otemae Hos Pitalja
dc.address.alternativethe Department of Urology, Komatsu Hospitalja
dc.address.alternativethe Department of Urology, Ikeda Municipal Hospitalja
dc.identifier.pmid9488944ja
Appears in Collections:Vol.43 No.12

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