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Title: PSA値Gray zoneにおける前立腺癌の診断 : Free及びTotal PSAの有用性
Other Titles: Free/total ratio of prostate-specific antigen (PSA) for prostate cancer detection in patients with gray zone PSA level
Authors: 田中, 方士  KAKEN_name
村上, 信乃  KAKEN_name
五十嵐, 辰男  KAKEN_name
阿部, 拓  KAKEN_name
鈴木, 孝一  KAKEN_name
関田, 信之  KAKEN_name
島崎, 淳  KAKEN_name
Author's alias: TANAKA, Masashi
ABE, Taku
SUZUKI, Koichi
SEKITA, Nobuyuki
Keywords: Prostate cancer
F/T ratio
Free PSA
Gray zone
Issue Date: Dec-1997
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 43
Issue: 12
Start page: 855
End page: 860
Abstract: Thirty seven patients complaining of voiding disturbance who showed gray zone total prostate-specific antigen (t-PSA) level (upper limit of normal approximately 10 ng/ml) but did not reveal apparent cancerous findings in the prostate were examined for free PSA (f-PSA) and prostate volume. According to histological diagnosis, 9 were cancer cases and the other 28 were non-cancer cases. The free/total (F/T) ratio was 0.10 and 0.16 in the cancer and non-cancer groups, respectively (t-PSA; DPC kit, p = 0.03). The t-PSA (DPC and Dinabott kits), f-PSA and PSA density alone did not distinguish these two groups. For diagnosis of cancer, the ratio seemed to be F/T, the most reliable followed by PSA density and t-PSA. When using a 13% F/T, the sensitivity and specificity for cancer detection were 88.9 and 70.8%, respectively. t-PSA measured with the Dinabott kit, showed a similar tendency except that the F/T ratio showed a slight variation. Prostate volume and patient age influenced the F/T slightly, but these factors may not impair the usefulness of F/T.
PubMed ID: 9488932
Appears in Collections:Vol.43 No.12

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