Neuroendocrine differentiationを伴った前立腺低分化腺癌の1例

Abstract

症例は59歳男で, 前立腺低分化腺癌と針生検によって診断され, ホルモン治療を開始し, ホルモン感受性が認められ一時は前立腺が縮少したもののその後ホルモン不応性となり急激に増大, 進行したneuroendocrine differentiationを伴った前立腺低分化腺癌例である.前立腺低分化腺癌と初めて診断されてから22ヵ月, NE differentiationを伴った前立腺低分化腺癌であることが判明してから3ヵ月という転機をとった

A 59-year-old man was diagnosed with clinical stage D1 poorly differentiated prostatic adenocarcinoma (PAC). The patient was treated with total androgen blockade therapy. The tumor recurred 18 months later. Digital rectal examination revealed a large, stony-hard prostate. The serum PSA level was within normal limits. Pathological examination of the prostate revealed conventional adenocarcinoma with large numbers of neuroendocrine (NE) cells. The patient died 3 months after the diagnosis of PAC with NE differentiation, 22 months after the initial diagnosis of prostate cancer.