前立腺癌診断直前のPSA倍加時間

Abstract

前立腺癌と診断される直前の段階で, 同一のキットでPSAを6ヵ月以上にわたり, 3回以上測定できた8例に関してPSA-DTを算出し, それと臨床病期, 組織学的分化度との関係について検討した. 1)PSAは, 時間に対して片対数グラフ上での回帰直線と良く相関した. 2)PSA-DTは, 最短5.1ヵ月から最長64.9ヵ月まで分布し, 平均23.1ヵ月であった. 3)PSA-DTと臨床病期, 組織学的分化度との間には, 統計学的に有意差はなかったが, 病期Dでは, B+Cに比べてPSA-DTが短い傾向であった. 4)8例のうち, 再燃したのは病期D, 低分化腺癌の1例のみで, その例のPSA-DTは5.1ヵ月と短かった

PSA-doubling time (PSA-DT) immediately before the diagnosis of prostate cancer was calculated in 8 prostate cancer patients in whom PSA was checked three or more times with the same kit during a period of 6 months or more. The correlation between PSA-DT and clinical stage or pathological differentiation was analyzed. In most patients, PSA correlated well showing a straight regression line to the observation period on a hemi-logarithmic scale. The correlation coefficient was high, almost 0.9 or more except in one patient. PSA-DT ranged from 5.1 to 64.9 months, averaging 23.1 months. There was no significant correlation between clinical stage or pathological differentiation and PSA-DT. However, PSA-DT in stage D patients tended to be shorter than that of stage B + C patients. One patient who had stage D poorly differentiated carcinoma died of cancer recurrence. In this patient, PSA-DT was short (5.1 months).