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Title: 80歳以上の超高齢者に対するBCG膀胱内注入療法の検討
Other Titles: Intravesical bacillus Calmette-Guerin instillation for patients over 80 years old
Authors: 兼松, 明弘  KAKEN_name
井上, 貴博  kyouindb  KAKEN_id
岩村, 浩志  KAKEN_name
高橋, 毅  KAKEN_name
清川, 岳彦  KAKEN_name
中野, 匡  KAKEN_name
筧, 善行  KAKEN_name
日裏, 勝  KAKEN_name
橋村, 孝幸  KAKEN_name
Author's alias: KANEMATSU, Akihiro
INOUE, Takahiro
IWAMURA, Hiroshi
SEGAWA, Takehiko
NAKANO, Tadasu
KAKEHI, Yoshiyuki
HIURA, Masaru
Keywords: Intravesical BCG instillation
Superficial bladder cancer
Elderly patients
Issue Date: Apr-1998
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 44
Issue: 4
Start page: 253
End page: 257
Abstract: 当科において施行した80歳以上と80歳未満の直接効果目的BCG療法施行群の治療成績を比較した.この年齢層においてもBCG膀注は施行可能であるが,その奏効率は80歳未満の症例よりも低かった
To study the efficacy and the safety of intravesical bacillus Calmette-Guerin (BCG) therapy for very elderly patients with superficial bladder cancer, we retrospectively compared patients over 80 years old who had received BCG therapy at our department between 1991 and 1996 (Group A; 10 patients 11 courses), with those below 80 years old (Group B, 17 patients 18 courses). In these patients, skin test reactivity to purified protein derivative showed a significant negative correlation with age (p = 0.016). No irreversible complications were observed in any patient. Persistence of acid-fast bacilli for more than one month after the termination of the course was observed in two patients in group A, and one in group B. A comparison of the cases undergoing eradicational BCG therapy in the two groups, grade 2 transitional cell carcinoma (TCC) was significantly more predominant than grade 3 TCC in group A (p = 0.004). (None of the tumors in group A were of grade 3) The disease-free rate was significantly lower in group A (p < 0.05), but 5 of the 10 patients in this group were finally disease-free. From these results, we conclude that intravesical BCG instillation therapy can be performed in patients over 80 years old, although a relatively lower disease-free rate is expected and special attention should be taken with regard to persistent BCG infection. The lower disease-free rate could be attributable to either diminished cellular immunity or a difference in tumor grade, although a definite conclusion could not be obtained here.
PubMed ID: 9617621
Appears in Collections:Vol.44 No.4

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