PSAが正常値を示した進行性前立腺癌症例の検討

Abstract

臨床病期C及びDの新鮮前立腺癌131症例中, 治療前の血清PSA値が正常値を示した10例の組織型は一定ではなく, 予後はかならずしも不良ではなかった.前立腺組織のPSA免疫染色で5例が陽性を示しその組織分化度は高い傾向であった.3例が陰性を示し, その組織分化度は低い傾向にあり, 2例は評価不能であった.再燃症状をきたした3例は, 再燃時には血清PSA値の上昇を認めなかった

Although prostate-specific antigen (PSA) is a valuable marker of prostate cancer, some untreated patients with advanced prostate cancer have normal PSA values. Over a period of 5 years, we reviewed pretreatment serum PSA levels in 131 patients with advanced prostate cancer (stages C and D). Ten patients (7.6%) had normal PSA values. The histological type of prostate cancer associated with normal PSA values was variable and the prognosis was not so poor. Immunostaining for PSA was performed on the resected prostate tissue of the 10 patients. PSA staining was positive in 5 cases, negative in 3 cases, and equivocal in the remaining 2 cases. In conclusion, PSA is not always useful, especially for following patients with normal PSA values.