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44_431.pdf | 12.09 MB | Adobe PDF | 見る/開く |
タイトル: | 女子急性単純性膀胱炎に対するFleroxacinの治療成績 : 3日間投与と7日間投与の比較検討 |
その他のタイトル: | Fleroxacin treatment for acute uncomplicated cystitis in women: comparison of 3-day and 7-day therapy |
著者: | 石原, 哲 坂, 義人 河田, 幸道 伊藤, 慎一 伊藤, 康久 土井, 達朗 山羽, 正義 伊藤, 文雄 上野, 一哉 篠田, 育男 簑島, 謙一 谷口, 光宏 竹内, 敏視 酒井, 俊助 根笹, 信一 藤広, 茂 岩田, 英樹 長谷川, 義和 宇野, 裕巳 小出, 卓也 |
著者名の別形: | ISHIHARA, Satoshi BAN, Yoshihito KAWADA, Yukimichi ITO, Shin-ichi ITO, Yasuhisa DOI, Tatsuro YAMAHA, Masayoshi ITO, Fumio UENO, Kazuya SHINODA, Ikuo MINOSHIMA, Ken-ichi TANIGUCHI, Mitsuhiro TAKEUCHI, Toshimi SAKAI, Shunsuke NEZASA, Shin-ichi FUJIHIRO, Shigeru IWATA, Hideki HASEGAWA, Yoshikazu UNO, Hiromi KOIDE, Takuya |
キーワード: | Acute uncomplicated cystitis Recurrence Fleroxacin |
発行日: | Jun-1998 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 44 |
号: | 6 |
開始ページ: | 431 |
終了ページ: | 436 |
抄録: | FLRXは急性単純性膀胱炎に対して3日間投与と7日間投与のいずれにおいても有効性が高かった.7日間投与は著効率が高く, 再発抑制の面でも若干優れているが, 有効率は同等で, 後者についても統計学的有意差は観察されず, 本剤は3日間投与でも十分効果の期待できる薬剤と思われた The clinical efficacy of fleroxacin (FLRX), a new fluoroquinolone, for acute uncomplicated cystitis (AUC) in women was assessed. Two regimens, 3-day and 7-day courses of FLRX, 200 mg once a day, were compared. Clinical and bacteriological efficacy were evaluated after the therapy, and recurrence rate was evaluated 1 week and 4 weeks after termination of the therapy. Of 136 registered subjects, 35 in the 3-day group and 47 in the 7-day group were evaluated. According to the criteria of Japanese UTI Committee (3rd edition), the rate of excellent results was significantly higher in the 7-day group (78.9%) than in the 3-day group (48.6%), but the overall clinical efficacy rate was similar being 100% and 97.9%, respectively. Although no recurrence was seen 1 week after the therapy in either group, recurrence was seen in 14.3% and 7.4% of the cases in the 3-day and 7-day groups, respectively, 4 weeks after the therapy. Adverse reactions were observed in 2 and 3 cases in the 3-day and 7-day groups, respectively. Both 3-day and 7-day regimens of FLRX treatment showed good efficacy. Although the 7-day treatment was superior to the 3-day treatment as to high rate of excellent results and low rate of recurrence, the 3-day treatment was concluded to be sufficient for AUC. |
URI: | http://hdl.handle.net/2433/116191 |
PubMed ID: | 9719946 |
出現コレクション: | Vol.44 No.6 |
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