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DCフィールド | 値 | 言語 |
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dc.contributor.author | 黒田, 加奈美 | ja |
dc.contributor.author | 石井, 延久 | ja |
dc.contributor.author | 白井, 将文 | ja |
dc.contributor.author | 田島, 政晴 | ja |
dc.contributor.author | 松島, 正浩 | ja |
dc.contributor.author | 高波, 真佐治 | ja |
dc.contributor.author | 松本, 英亜 | ja |
dc.contributor.author | 深澤, 潔 | ja |
dc.contributor.author | 三浦, 一陽 | ja |
dc.contributor.author | 松橋, 求 | ja |
dc.contributor.author | 桑原, 孝 | ja |
dc.contributor.author | 杉田, 稔 | ja |
dc.contributor.alternative | KURODA, Kanami | en |
dc.contributor.alternative | ISHII, Nobuhisa | en |
dc.contributor.alternative | SHIRAI, Masafumi | en |
dc.contributor.alternative | TAJIMA, Masaharu | en |
dc.contributor.alternative | MATSUSHIMA, Masahiro | en |
dc.contributor.alternative | TAKANAMI, Masaharu | en |
dc.contributor.alternative | MATSUMOTO, Hidetsugu | en |
dc.contributor.alternative | FUKASAWA, Kiyoshi | en |
dc.contributor.alternative | MIURA, Kazukiyo | en |
dc.contributor.alternative | MATSUHASHI, Motomu | en |
dc.contributor.alternative | KUWABARA, Takashi | en |
dc.contributor.alternative | SUGITA, Minoru | en |
dc.date.accessioned | 2010-05-28T06:21:01Z | - |
dc.date.available | 2010-05-28T06:21:01Z | - |
dc.date.issued | 1998-08 | - |
dc.identifier.issn | 0018-1994 | - |
dc.identifier.uri | http://hdl.handle.net/2433/116240 | - |
dc.description.abstract | 術直後に集中して行うTHPの5分間膀胱内注入療法は, 表在性膀胱癌の再発予防に対して安全かつ有効な治療方法と思われる | ja |
dc.description.abstract | We conducted a prospective randomized controlled study on the prophylactic effects of short-term intravesical instillation of pirarubicin (THP) against recurrence to determine the effective administration schedule. All patients gave their informed consent. The subjects included bladder cancer patients who had pTa or pT1, and G1 or G2 cancer, and became tumor-free after transurethral resection of the bladder tumor (TUR-BT). After dissolving 30 mg of THP into 5 ml of distilled water, physiological saline was added to adjust the total volume to 50 ml, which was then instilled into the bladder, and was retained for 5 minutes. The schedule of instillation was for daily for 7 consecutive days from the day of TUR-BT and subsequently once a week for 10 weeks, 17 times in total for Group I, and once every two weeks for 6 months (12 times) starting 2 weeks after TUR and subsequently once a month until one year had passed after surgery (6 times), 18 times in total for Group II. The total number of cases was 69 (36 in Group I, 33 in Group II). The tumor-free ratios determined by the Kaplan-Meier analysis were 93.9% in Group I and 72.7% in Group II for one year, and 86.8% in Group I and 59.5% in Group II for two years. There was a statistically significant difference in the tumor-free ratios between the two groups by the generalized Wilcoxon test and the Log rank test (p = 0.0145 and 0.0107, respectively). Multivariated analysis using Cox's comparison hazard model produced p-values of 0.0002, 0.0007, 0.0009 and 0.0040 in the order of therapeutic mode, initial onset/recurrence, stage and number of tumor. Adverse events that forced discontinuation of the therapy for a while occurred in 4.3%. These results demonstrated that short-term intensive intravesical instillation of THP immediately after TUR-BT was a safe and effective therapy. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | jpn | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.subject | Superficial bladder cancer | en |
dc.subject | Pirarubicin (THP) | en |
dc.subject | Intravesical chemotherapy | en |
dc.subject | Prophylaxis oftumor recurrence | en |
dc.subject.ndc | 494.9 | - |
dc.title | 表在性膀胱癌に対するピラルビシン(THP)短時間膀胱内注入療法の再発予防効果について | ja |
dc.title.alternative | Short-term intravesical instillation of pirarubicin (THP) in prophylactic treatment after transurethral resection of superficial bladder tumor | en |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 44 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 547 | - |
dc.identifier.epage | 552 | - |
dc.textversion | publisher | - |
dc.sortkey | 02 | - |
dc.address | 東邦大学医学部泌尿器科学第一講座 | ja |
dc.address | 東邦大学医学部泌尿器科学第一講座 | ja |
dc.address | 東邦大学医学部泌尿器科学第一講座 | ja |
dc.address | 東邦大学医学部泌尿器科学第二講座 | ja |
dc.address | 東邦大学医学部泌尿器科学第二講座 | ja |
dc.address | 東邦大学医学部附属佐倉病院 | ja |
dc.address | 社会保険中央総合病院泌尿器科 | ja |
dc.address | 済生会横浜市南部病院泌尿器科 | ja |
dc.address | 社会保険桜ケ丘総合病院泌尿器科 | ja |
dc.address | 健保総合川崎中央病院泌尿器科 | ja |
dc.address | 健保総合川崎中央病院泌尿器科 | ja |
dc.address | 東邦大学医学部衛生学講座 | ja |
dc.address.alternative | the1st Department of Urology, Toho University School of Medicine | en |
dc.address.alternative | the1st Department of Urology, Toho University School of Medicine | en |
dc.address.alternative | the1st Department of Urology, Toho University School of Medicine | en |
dc.address.alternative | the2nd Department of Urology, Toho University School of Medicine | en |
dc.address.alternative | the2nd Department of Urology, Toho University School of Medicine | en |
dc.address.alternative | the Department of Urology, Sakura Hospital | en |
dc.address.alternative | the Department of Urology S, ocial Insurance Central Hospital | en |
dc.address.alternative | the Department of Urology, Saiseikai Yokohama-shi Nambu Hospital | en |
dc.address.alternative | the Department of Urology, Social Insurance Sakuragaoka Hospital | en |
dc.address.alternative | the Department of Urology, Social Insurance Kawasaki Central Hospital | en |
dc.address.alternative | the Department of Urology, Social Insurance Kawasaki Central Hospital | en |
dc.address.alternative | the Department of Environmentaland Occupational Health, Toho University School of Medicine | en |
dc.identifier.pmid | 9783189 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.44 No.8 |
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